[Ph3SnONCH3C(O)C6H4Br-2] | 1613294-29-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [Ph3SnONCH3C(O)C6H4Br-2]
• 英文别名: triphenyltin(IV) N-methyl o-bromobenzohydroxamate；[Ph₃SnONCH₃C(O)C₆H₄Br-2]
• CAS: 1613294-29-3
• 化学式: C₂₆H₂₂BrNO₂Sn
• 分子量: 579.08
• InChiKey: IAEPTCOCBOTNKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  [Ph3SnONCH3C(O)C6H4Br-2] 生成 tin(IV) oxide
  参考文献：
  名称：

  Triorganotin(IV) complexes with o-substituted arylhydroxamates: Synthesis, spectroscopic characterization, X-ray structures and in vitro cytotoxic activities

  摘要：

  Six new triorganotin(IV) complexes with six different RN-2-X-benzohydroxamic acid ligands having general formula R'C(O)N(RN)OH (R' = alkyl/aryl; RN = alkyl/aryl or H), (X = -I, -NO2, -OCH3, -Br and R = -CH3, -C6H5 and -C6H4-CH3), were prepared by condensation method with the respective organotin(IV) chlorides using a stoichiometric ratio of 1:1. The bonding and coordination behaviour of these complexes were investigated on the basis of FT-IR, multinuclear H-1, C-13 and Sn-119 NMR spectroscopies. Complexes (1) and (3) crystallize in the orthorhombic P2(1)2(1)2(1) space group and complex (2) crystallizes in the triclinic P-1 space group whereas complex (4) crystallizes in the monoclinic P2(1)/c space group. The tested triphenyltin(IV) complexes showed significant cytotoxicities, higher than doxorubicin toward K-562, Jurkat, HepG2 and L929 cells. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2014.04.015
• 作为产物：
  描述：

  N-methyl-N-(2-bromobenzoyl)hydroxylamine 、 三苯基氯化锡 在 potassium hydroxide 作用下， 以 甲醇 、 四氢呋喃 为溶剂， 反应 4.0h， 以78%的产率得到[Ph3SnONCH3C(O)C6H4Br-2]
  参考文献：
  名称：

  Triorganotin(IV) complexes with o-substituted arylhydroxamates: Synthesis, spectroscopic characterization, X-ray structures and in vitro cytotoxic activities

  摘要：

  Six new triorganotin(IV) complexes with six different RN-2-X-benzohydroxamic acid ligands having general formula R'C(O)N(RN)OH (R' = alkyl/aryl; RN = alkyl/aryl or H), (X = -I, -NO2, -OCH3, -Br and R = -CH3, -C6H5 and -C6H4-CH3), were prepared by condensation method with the respective organotin(IV) chlorides using a stoichiometric ratio of 1:1. The bonding and coordination behaviour of these complexes were investigated on the basis of FT-IR, multinuclear H-1, C-13 and Sn-119 NMR spectroscopies. Complexes (1) and (3) crystallize in the orthorhombic P2(1)2(1)2(1) space group and complex (2) crystallizes in the triclinic P-1 space group whereas complex (4) crystallizes in the monoclinic P2(1)/c space group. The tested triphenyltin(IV) complexes showed significant cytotoxicities, higher than doxorubicin toward K-562, Jurkat, HepG2 and L929 cells. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2014.04.015