8-Ethoxycarbonylaminocarbostyril | 23862-62-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-Ethoxycarbonylaminocarbostyril
• 英文别名: (2-oxo-1,2-dihydro-quinolin-8-yl)-carbamic acid ethyl ester；ethyl N-(2-oxo-1H-quinolin-8-yl)carbamate
• CAS: 23862-62-6
• 化学式: C₁₂H₁₂N₂O₃
• 分子量: 232.239
• InChiKey: YEARINFGSRRVSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• AMINO-PYRIDINE, -PYRIDINE AND PYRIDAZINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN
  申请人：Amgen Inc.

  公开号：EP1542692A1

  公开（公告）日：2005-06-22
• [EN] AMINO-PYRIDINE, -PYRIDINE AND PYRIDAZINE DERIVATIVES FOR USE AS VANILLOID RECEPTOR LIGANDS FOR THE TREATMENT OF PAIN<br/>[FR] AMINO-PYRIDINE, DERIVES DE PYRIDINE ET DE PYRIDAZINE UTILISES COMME LIGANDS DE RECEPTEUR VANILLOIDE PERMETTANT DE TRAITER UNE DOULEUR
  申请人：AMGEN INC

  公开号：WO2003099284A1

  公开（公告）日：2003-12-04

  Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.