4-溴吡啶-2-乙酸甲酯 | 192642-94-7

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 4-溴吡啶-2-乙酸甲酯
• 英文名称: (4‐bromo‐2‐pyridyl)methyl acetate
• 英文别名: acetic acid 4-bromopyridin-2-ylmethyl ester；(4-Bromopyridin-2-yl)methyl acetate
• CAS: 192642-94-7
• 化学式: C₈H₈BrNO₂
• 分子量: 230.061
• InChiKey: NAODUHQACVSGGR-UHFFFAOYSA-N

物化性质

• 沸点：
  275.5±25.0 °C(Predicted)
• 密度：
  1.517±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为反应物：
  描述：

  4-溴吡啶-2-乙酸甲酯 在 盐酸 、 草酰氯 、 sodium methylate 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 105.0h， 生成 5-methoxy-[1,2,3]triazolo[1,5-a]pyridine
  参考文献：
  名称：

  三唑并吡啶。18.对三唑并吡啶的亲核取代反应；2,2'-联吡啶的新途径

  摘要：

  描述了一些5-，6-和7-卤代三唑并吡啶的合成，以及它们与亲核试剂的反应。7,7'-双氮杂吡啶吡啶的形成提供了2,2'-联吡啶的新合成。

  DOI：

  10.1016/s0040-4020(97)00491-2
• 作为产物：
  描述：

  4-溴-2-甲基吡啶 在 间氯过氧苯甲酸 作用下， 以 氯仿 为溶剂， 反应 2.0h， 生成 4-溴吡啶-2-乙酸甲酯
  参考文献：
  名称：

  Anchoring a Molecular Iron Catalyst to Solar-Responsive WO₃ Improves the Rate and Selectivity of Photoelectrochemical Water Oxidation

  摘要：

  Molecular catalysts help overcome the kinetic limitations of water oxidation and generally result in faster rates for water oxidation than do heterogeneous catalysts. However, molecular catalysts typically function in the dark and therefore require sacrificial oxidants such as Ce4+ or S2O82- to provide the driving force for the reaction. In this Communication, covalently anchoring a phosphonate-derivatized complex, Fe(tebppmcn)Cl-2 (1), to WO3 removes the need for a sacrificial oxidant and increases the rate of photoelectrochemical water oxidation on WO3 by 60%. The dual-action catalyst, 1-WO3, also gives rise to increased selectivity for water oxidation in pH 3 Na2SO4 (56% on bare WO3, 79% on 1-WO3). This approach provides promising alternative routes for solar water oxidation.

  DOI：

  10.1021/ja4086808

文献信息

• Design of a Hybrid Biosensor for Enhanced Phosphopeptide Recognition Based on a Phosphoprotein Binding Domain Coupled with a Fluorescent Chemosensor
  作者：Takahiro Anai、Eiji Nakata、Yoichiro Koshi、Akio Ojida、Itaru Hamachi

  DOI：10.1021/ja0693284

  日期：2007.5.1

  biosensors with sufficient sensing specificity are useful analytical tools for detection of biologically important substances in complicated biological systems. Here, we present the design of a hybrid biosensor, specific for a bis-phosphorylated peptide, based on a natural phosphoprotein binding domain coupled with an artificial fluorescent chemosensor. The hybrid biosensor consists of a phosphoprotein binding

  具有足够传感特异性的基于蛋白质的荧光生物传感器是检测复杂生物系统中重要生物物质的有用分析工具。在这里，我们基于天然磷蛋白结合域与人工荧光化学传感器设计了一种混合生物传感器，专用于双磷酸化肽。混合生物传感器由磷蛋白结合域组成，即 WW 域，其中引入了具有 Zn(II)-二吡啶甲胺 (Dpa) 作为磷酸结合基序的荧光 stilbazole。在各种磷酸盐物质（如单磷酸化肽、ATP 等）存在的情况下，它对特定的双磷酸化肽表现出很强的结合亲和力和高传感选择性。详细的荧光滴定实验清楚地表明，结合诱导的荧光增强和传感选择性是通过混合生物传感器的两个结合位点，即 WW 结构域和 Zn(II)-Dpa 化学传感器单元的协同作用实现的。因此，很明显，拴系的 Zn(II)-Dpa-stilbazole 单元不仅作为荧光信号传感器，而且作为混合生物传感器中的亚结合位点。利用其选择性传感特性，混合生物传感器成功应用
• [EN] GPR52 MODULATORS AND METHODS OF USE<br/>[FR] MODULATEURS DE GPR52 ET PROCÉDÉS D'UTILISATION
  申请人：NEUROCRINE BIOSCIENCES INC

  公开号：WO2021216705A1

  公开（公告）日：2021-10-28

  The present disclosure relates to compounds of Formula (I) that modulate the activity of G-protein coupled receptor 52 (GPR52), pharmaceutically acceptable salts of compounds of Formula (I), and pharmaceutical compositions thereof. Compounds, pharmaceutical salts of compounds, and pharmaceutical compositions of the present disclosure are directed to methods useful in the treatment or prophylaxis of a neurological disease or disorder and conditions related thereto.

  本公开涉及式(I)化合物，该化合物调节G蛋白偶联受体52（GPR52）的活性，化合物的药学可接受盐以及其制备的药物组合物。本公开的化合物、化合物的药学盐以及药物组合物，用于治疗或预防神经系统疾病或障碍及相关疾病的方法。
• Triazolopyrazine compounds useful for the treatment of degenerative & inflammatory diseases
  申请人：Andrews Inglis Martin James

  公开号：US20080090818A1

  公开（公告）日：2008-04-17

  Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

  本发明揭示了一种Novel [1.2.4]triazolo[1,5-a]pyrazine化合物，其化学式如下：这些化合物可以制备成药物组成物，并可用于哺乳动物包括人类的预防和治疗多种疾病，例如，但不限于疼痛、炎症等。
• TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
  申请人：Andrews Martin James Inglis

  公开号：US20110178067A1

  公开（公告）日：2011-07-21

  Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

  揭示了一种Novel [1.2.4]三唑并[1,5-a]吡嗪化合物，其化学式如下：这些化合物可以制备为药物组合物，并可用于哺乳动物，包括人类的预防和治疗多种病症，例如疼痛、炎症等，但不限于此。
• Triazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
  申请人：Galapagos NV

  公开号：US07915256B2

  公开（公告）日：2011-03-29

  Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, and others.

  公开了一种Novel [1.2.4]三唑并[1,5-a]吡嗪化合物，其化学式如下所示：这些化合物可以制备成药物组合物，并可用于哺乳动物（包括人类）的预防和治疗多种疾病，例如疼痛、炎症等等。