49Wmw4VH6D | 473839-19-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 49Wmw4VH6D
• 英文别名: 7-[(4R)-4-amino-3,3-dimethylpiperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid
• CAS: 473839-19-9
• 化学式: C₂₁H₂₆FN₃O₄
• 分子量: 403.4
• InChiKey: PMBHAWNZPPNADR-OAHLLOKOSA-N

物化性质

• 沸点：
  601.5±55.0 °C(Predicted)
• 密度：
  1.341±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  96.1
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• POLYMORPHS OF 1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-(4-AMINO-3, 3-DIMETHYLPIPERIDIN-1-YL)-1,4-DIHYDRO-4-OXO-QUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE AND MESALYTE SALTS
  申请人：Wockhardt Limited

  公开号：EP1694667A2

  公开（公告）日：2006-08-30
• Novel polymorphs of racemic, dextrorotatory, and levorotatory enationers of 1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo- quinoline-3-carboxylic acid hydrochloride and mesylate salts
  申请人：Deshpande Keshav Prasad

  公开号：US20070082926A1

  公开（公告）日：2007-04-12

  A polymorphic forms of the hydrochloride salt and mesylate salt of racemic (±)-1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid, dextrorotatory R-(±)-1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and S-(−)-1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro- 4 -oxo-quinoline-3-carboxylic acid having formula (I) and (II) respectively are described. Processes for their preparation are also described. The invention further relates to methods of using, and pharmaceutical compositions comprising the compounds of the invention for treatment of bacterial infections in mammals.
• US7538221B2
  申请人：——

  公开号：US7538221B2

  公开（公告）日：2009-05-26
• [EN] NOVEL POLYMORPHS OF RACEMIC, DEXTROROTATORY, AND LEVOROTATORY ENANTIONERS OF 1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-(4-AMINO-3,3-DIMETHYLPIPERIDIN-1-YL)-1,4-DIHYDRO-4-OXO-QUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE AND MESYLATE SALTS<br/>[FR] NOUVEAUX POLYMORPHES D'ENANTIOMERES RACEMIQUES, DEXTROGYRES ET LEVOGYRES DE SELS DE CHLORHYDRATE ET DE MESYLATE D'ACIDE 1-CYCLOPROPYL-6-FLUORO-8-METHOXY-7-(4-AMINO-3,3-DIMETHYLPIPERIDIN-1-YL)-1,4-DIHYDRO-4-OXO-QUINOLINE-3-CARBOXYLIQUE
  申请人：DESHPANDE PRASAD KESHAV

  公开号：WO2005066154A2

  公开（公告）日：2005-07-21

  A polymorphic forms of the hydrochloride salt and mesylate salt of racemic (±)-1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid, dextrorotatory R-(+)-1-cyclopropyl-ó-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid and S-(-)-1-cyclopropyl-6-fluoro-8-methoxy-7-(4-amino-3,3-dimethylpiperidin-1-yl)-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid having formula (I) and (II) respectively are described. Processes for their preparation are also described. The invention further relates to methods of using, and pharmaceutical compositions comprising the compounds of the invention for treatment of bacterial infections in mammals.