1-(3-Chlor-phenyl)-4,5-dimethyl-imidazol | 31033-76-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(3-Chlor-phenyl)-4,5-dimethyl-imidazol
• 英文别名: 1-(m-Chlorphenyl)-4,5-dimethylimidazol；1-(3-chloro-phenyl)-4,5-dimethyl-1H-imidazole；1-(3-Chlorophenyl)-4,5-dimethylimidazole；1-(3-chlorophenyl)-4,5-dimethylimidazole
• CAS: 31033-76-8
• 化学式: C₁₁H₁₁ClN₂
• 分子量: 206.675
• InChiKey: VQQIYHGIIKMQKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  在 铁粉 、 溶剂黄146 作用下， 反应 2.0h， 以90%的产率得到1-(3-Chlor-phenyl)-4,5-dimethyl-imidazol
  参考文献：
  名称：

  Synthesis of 2-unsubstituted 1-arylimidazoles

  摘要：

  A method has been developed for the synthesis of 1-arylimidazoles lacking a substituent at position 2, featuring the preparation of 1-arylimidazole N-oxides stabilized as boron trifluoride derivatives, with subsequent reduction to the desired imidazoles. This method permits broad variation of the substituents in the aryl part of these molecules.

  DOI：

  10.1007/s10593-013-1210-8

文献信息

• Synthesis of 2-unsubstituted 1-arylimidazoles
  作者：V. S. Mityanov、V. P. Perevalov、I. I. Tkach

  DOI：10.1007/s10593-013-1210-8

  日期：2013.3

  A method has been developed for the synthesis of 1-arylimidazoles lacking a substituent at position 2, featuring the preparation of 1-arylimidazole N-oxides stabilized as boron trifluoride derivatives, with subsequent reduction to the desired imidazoles. This method permits broad variation of the substituents in the aryl part of these molecules.