(8S,9R,5Z,10Z,12E,14E,17Z)-8,9-dihydroxy-5,10,12,14,17-eicosapentaenoic acid | 157461-97-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (8S,9R,5Z,10Z,12E,14E,17Z)-8,9-dihydroxy-5,10,12,14,17-eicosapentaenoic acid
• 英文别名: (5Z,8S,9R,10Z,12E,14E,17Z)-8,9-dihydroxyicosa-5,10,12,14,17-pentaenoic acid
• CAS: 157461-97-7
• 化学式: C₂₀H₃₀O₄
• 分子量: 334.456
• InChiKey: WYFRLICIOXDFMB-VRHUZPIRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (8S,9R,5Z,10Z,12E,14E,17Z)-8,9-dihydroxy-5,10,12,14,17-eicosapentaenoic acid 在 4-二甲氨基吡啶 、 2,4,6-三氯苯甲酰氯 、 三乙胺 作用下， 生成 、 (8S,9R)-didemnilactone
  参考文献：
  名称：

  Didemnilactones A and B and neodidemnilactone three new fatty acid metabolites isolated from the tunicate Didemnum moseleyi (Herdman)

  摘要：

  Three new fatty acid metabolites didemnilactones A (1) and B (2) and neodidemnilactone (3) were isolated from the tunicate Didemnum moseleyi (Herdman). Their structures including absolute stereochemistry were established on the basis of spectral studies and chemical synthesis. Didemnilactones exhibited inhibitory activity against lipoxygenase and weak binding activity to leukotriene B-4 receptors.

  DOI：

  10.1016/s0040-4020(01)90469-7
• 作为产物：
  描述：

  4-羧丁基三苯基溴化膦 在 lithium hydroxide 、 草酰氯 、 sodium hexamethyldisilazane 、 二甲基亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 水 、 溶剂黄146 为溶剂， 反应 48.05h， 生成 (8S,9R,5Z,10Z,12E,14E,17Z)-8,9-dihydroxy-5,10,12,14,17-eicosapentaenoic acid
  参考文献：
  名称：

  Didemnilactones A and B and neodidemnilactone three new fatty acid metabolites isolated from the tunicate Didemnum moseleyi (Herdman)

  摘要：

  Three new fatty acid metabolites didemnilactones A (1) and B (2) and neodidemnilactone (3) were isolated from the tunicate Didemnum moseleyi (Herdman). Their structures including absolute stereochemistry were established on the basis of spectral studies and chemical synthesis. Didemnilactones exhibited inhibitory activity against lipoxygenase and weak binding activity to leukotriene B-4 receptors.

  DOI：

  10.1016/s0040-4020(01)90469-7

文献信息

• Didemnilactones A and B and neodidemnilactone three new fatty acid metabolites isolated from the tunicate Didemnum moseleyi (Herdman)
  作者：Haruki Niwa、Masaru Watanabe、Hideaki Inagaki、Kiyoyuki Yamada

  DOI：10.1016/s0040-4020(01)90469-7

  日期：——

  Three new fatty acid metabolites didemnilactones A (1) and B (2) and neodidemnilactone (3) were isolated from the tunicate Didemnum moseleyi (Herdman). Their structures including absolute stereochemistry were established on the basis of spectral studies and chemical synthesis. Didemnilactones exhibited inhibitory activity against lipoxygenase and weak binding activity to leukotriene B-4 receptors.