3,3,4,4-Tetrafluoro-4-bromobutanal | 200624-01-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,3,4,4-Tetrafluoro-4-bromobutanal
• 英文别名: 4-bromo-3,3,4,4-tetrafluorobutanal
• CAS: 200624-01-7
• 化学式: C₄H₃BrF₄O
• 分子量: 222.965
• InChiKey: KSCWKQWJAMXEGM-UHFFFAOYSA-N

物化性质

• 沸点：
  114.2±40.0 °C(Predicted)
• 密度：
  1.756±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  苯胺 、 3,3,4,4-Tetrafluoro-4-bromobutanal 以 溶剂黄146 为溶剂， 反应 8.0h， 以58%的产率得到2-bromodifluoromethyl-quinoline
  参考文献：
  名称：

  A Novel Synthesis of 2-Fluoroalkyl Quinolines

  摘要：

  2-Fluoroalkyl quinolines are prepared by reacting aniline with alpha-fluoroalkyl aldehydes or alpha-fluoroalkyl cyclohexanones in the presence of acetic acid. Under the same reaction condition, 2-aminophenol gives the corresponding 2-fluoroalkyl-8-quinolinols; in some cases, 2-fluoroalkyl benzoxazoles are also formed as minor products.

  DOI：

  10.1007/s007060050006
• 作为产物：
  描述：

  1-溴-2-碘四氟乙烷 、 乙烯基乙醚 在 sodium dithionite 作用下， 以 水 、 乙腈 为溶剂， 生成 3,3,4,4-Tetrafluoro-4-bromobutanal
  参考文献：
  名称：

  Synthesis of 5-per(poly)fluoroalkyl-2,3-dihydro-1,4-diazepines

  摘要：

  a series of 5-per(poly)fluoroalkyl-2,3-dihydro-1,4-diazepines were synthesized from alpha-per(poly)fluoroalkyl aldehydes and ethylenediamine. A possible reaction pathway was suggested. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00261-5

文献信息

• One Pot Synthesis of Fluoroalkyl Pyrimidines from α-Fluoroalkyl Carbonyl Compounds, Orthoesters and Ammonium Carbonate
  作者：Bing-Hao Luo、Hui-Ping Guan、Chang-Ming Hu

  DOI：10.1055/s-1997-1031

  日期：1997.11

  Fluoroalkyl pyrimidines have been synthesized from one pot reaction of α-fluoroalkyl carbonyl compounds, orthoesters and ammonium carbonate. The possible reaction pathway is suggested.

  氟烷基嘧啶是由δ-氟烷基羰基化合物、原生酯和碳酸铵的一锅反应合成的。提出了可能的反应途径。
• A novel synthesis of 2-per(poly)fluoroalkyl-1H-benzimidazoles or 2-per(poly) fluoroalkyl benzothiazoles
  作者：Quan-Fu Wang、Yun-Yu Mao、Shi-Zheng Zhu、Chang-Ming Hu

  DOI：10.1016/s0022-1139(99)00012-3

  日期：1999.6

  A new method for the preparation of 2-per(poly)fluoroalkyl-1H-benzimidazoles or 2-per(poly)fluoroalkyl benzothiazoles from reaction of readily available alpha-per(poly)fluoroalkyl aldehydes with o-phenylenediamine or 2-aminobenzenethiol is presented. A possible reaction pathway is suggested. (C) 1999 Elsevier Science S.A. All rights reserved.