4-oxo-4-[4'-(l,1,2,2-tetrafluoroethoxy)biphenyl-4-yl]butyric acid | 405167-41-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-oxo-4-[4'-(l,1,2,2-tetrafluoroethoxy)biphenyl-4-yl]butyric acid
• 英文别名: 4-Oxo-4-[4-[4-(1,1,2,2-tetrafluoroethoxy)phenyl]phenyl]butanoic acid
• CAS: 405167-41-1
• 化学式: C₁₈H₁₄F₄O₄
• 分子量: 370.3
• InChiKey: YLZBOEDPRWATCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Method for producing ketocarboxylic acid derivatives
  申请人：——

  公开号：US20030220517A1

  公开（公告）日：2003-11-27

  A novel process affords &ohgr;-ketocarboxylic acid derivatives of the formula (I) 1 in which R 1 , R 2 , R 3 , and n are as defined in the description by reaction of compounds of the formula (II) 2 with compounds of the formula (III) 3 or with compounds of the formula (IV) 4 in which m is as defined in the description in anhydrous hydrogen fluoride, if appropriate in the presence of boron trifluoride. Novel &ohgr;-ketocarboxylic acid derivatives of the formula (If) 5 in which R 1-1 , R 2−1 , R 3−1 and q are as defined in the description.

  一种新的工艺通过化合物（II）2的反应与化合物（III）3或化合物（IV）4在无水氢氟酸中（必要时在三氟化硼存在下）制备了式（I）1的&ohgr;-酮羧酸衍生物，其中R1、R2、R3和n如描述中定义。新的&ohgr;-酮羧酸衍生物的化学式为（If）5，其中R1-1、R2-1、R3-1和q如描述中定义。