WP1127 | 857064-76-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: WP1127
• 英文别名: [(2R,3S,4S,5R,6R)-4,5,6-triacetyloxy-2-[[[(E)-3-(6-bromopyridin-2-yl)-2-cyanoprop-2-enoyl]amino]methyl]oxan-3-yl] acetate
• CAS: 857064-76-7
• 化学式: C₂₃H₂₄BrN₃O₁₀
• 分子量: 582.362
• InChiKey: ILPPVCZZYYLYBA-OYFQMMMJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  37
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  180
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• INTERFERON THERAPIES IN COMBINATION WITH BLOCKADE OF STAT3 ACTIVATION
  申请人：Board of Regents, The University of Texas System

  公开号：EP2506852A2

  公开（公告）日：2012-10-10
• COMPOUNDS FOR TREATMENT OF CELL PROLIFERATIVE DISEASES
  申请人：Priebe Waldemar

  公开号：US20110021805A1

  公开（公告）日：2011-01-27

  The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.
• METHODS OF TREATING DERMATOLOGIC, GYNECOLOGIC, AND GENITAL DISORDERS WITH CAFFEIC ACID ANALOGS
  申请人：Priebe Anna

  公开号：US20110275577A1

  公开（公告）日：2011-11-10

  The present invention relates to caffeic acid analog compounds and methods which may be useful for regeneration, cellular programming, and the treatment of dermatologic, gynecologic, and genital diseases such as inflammatory dermatologic conditions, dysplasia, neoplasia, in situ carcinoma, invasive carcinoma, lichen sclerosus, lichen planus, vaginal dysplasia, vaginal carcinoma, vulvar dysplasia, vulvar carcinoma, cervical dysplasia, cervical carcinoma, and Kaposi's sarcoma.
• US8119827B2
  申请人：——

  公开号：US8119827B2

  公开（公告）日：2012-02-21
• US8648102B2
  申请人：——

  公开号：US8648102B2

  公开（公告）日：2014-02-11