3-chloro-2-fluoro-5-(trifluoromethyl)benzyltriphenylphosphonium bromide | 497961-20-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-chloro-2-fluoro-5-(trifluoromethyl)benzyltriphenylphosphonium bromide
• 英文别名: [3-Chloro-2-fluoro-5-(trifluoromethyl)phenyl]methyl-triphenylphosphanium;bromide
• CAS: 497961-20-3
• 化学式: Br*C₂₆H₁₉ClF₄P
• 分子量: 553.761
• InChiKey: CFLWCRAQGFTQON-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  4.0
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-chloro-2-fluoro-5-(trifluoromethyl)benzyltriphenylphosphonium bromide 、 在 potassium tert-butylate 作用下， 以 N,N-二甲基甲酰胺 、 叔丁醇 为溶剂， 反应 1.17h， 生成 、
  参考文献：
  名称：

  NOVEL SYNTHETIC GANGLIOSIDE DERIVATIVES AND COMPOSITIONS THEREOF

  摘要：

  公开号：

  EP1435972B1
• 作为试剂：
  描述：

  在 3-chloro-2-fluoro-5-(trifluoromethyl)benzyltriphenylphosphonium bromide 、 potassium tert-butylate 作用下， 以 DMF (N,N-dimethyl-formamide) 、 叔丁醇 为溶剂， 反应 1.0h， 以42%的产率得到
  参考文献：
  名称：

  WO2004/80960

  摘要：

  公开号：

文献信息

• Novel synthetic ganglioside derivatives and compositions thereof
  申请人：Defrees Shawn

  公开号：US20050239741A1

  公开（公告）日：2005-10-27

  Novel synthetic gangliosides and pharmaceutical compositions containing such synthetic gangliosides are described. Methods of making the novel synthetic ganglioside compounds and compositions as well as their use in the field of neuroprotection and cancer treatment is also described.

  本文描述了新型合成神经节苷脂和含有此类合成神经节苷脂的药物组合物。还介绍了制造新型合成神经节苷脂化合物和组合物的方法，以及它们在神经保护和癌症治疗领域的用途。
• EP1435972A4
  申请人：——

  公开号：EP1435972A4

  公开（公告）日：2006-03-22
• METHODS AND COMPOSITIONS FOR THE ENZYMATIC SYNTHESIS OF GANGLIOSIDES
  申请人：Seneb Biosciences Inc.

  公开号：EP1603932B1

  公开（公告）日：2012-10-03
• Methods and Compositions for the Enzymatic Synthesis of Gangliosides
  申请人：Defrees A. Shawn

  公开号：US20070275908A1

  公开（公告）日：2007-11-29

  Novel synthetic glycosphingolipids and pharmaceutical compositions containing such synthetic glycosphingolipids are described. Methods of making the novel synthetic glycosphingolipid compounds and compositions as well as their use in the field of neuroprotection and cancer treatment is also described.
• TREATMENT OF PARKINSONS DISEASE WITH GLYCOLIPIDS
  申请人：Rutgers, The State University of New Jersey

  公开号：US20140187507A1

  公开（公告）日：2014-07-03

  This invention provides compounds, compositions, and methods for treating Parkinson's disease. In particular, there is provided GM1 ganglioside analogs that are capable of penetrating the blood brain barrier and entering the cytoplasm of neurons. Endogenous GM1 interacts with the with GFRα1/RET, the GDNF receptor complex involved in GDNF signaling which is essential for neuron survival. In neurons that are deficient in endogenous GM1, the GM1 analog compounds of the invention are capable of restoring GDNF signaling thereby preventing neuron cell death.