3-[1-(6-chloro-1H-indole-3-carbonyl)-piperidin-4-yl]-3H-benzooxazol-2-one | 1036322-61-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-[1-(6-chloro-1H-indole-3-carbonyl)-piperidin-4-yl]-3H-benzooxazol-2-one
• 英文别名: 3-[1-(6-chloro-1H-indole-3-carbonyl)piperidin-4-yl]-1,3-benzoxazol-2-one
• CAS: 1036322-61-8
• 化学式: C₂₁H₁₈ClN₃O₃
• 分子量: 395.845
• InChiKey: FAXYFOQDAWRIOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  65.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• INDOLES
  申请人：Bissantz Caterina

  公开号：US20080161315A1

  公开（公告）日：2008-07-03

  The present invention is concerned with novel indol-3-yl-carbonyl-piperidine-benzopyrrolone, -benzoxazolone and -benzotriazole derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use for the treatment of anxiety and depressive disorders and other diseases. In particular, the present invention is concerned with compounds of formula (I) wherein X, Y and R 1 to R 10 are as described in the specification.

  本发明涉及新型吲哚-3-基-羰基-哌啶-苯并吡咯酮、苯并噁唑酮和苯并三唑衍生物作为V1a受体拮抗剂，它们的制备、含有它们的药物组合物以及它们用于治疗焦虑和抑郁症等疾病的用途。具体而言，本发明涉及具有式(I)的化合物，其中X、Y和R1至R10如规范中所述。
• INDOLE-3-YL-CARBONYL-PIPERIDINE- DERIVATIVES FOR THE TREATMENT OF ANXIETY AND DEPRESSIVE DISORDERS VIA V1A RECEPTOR ANTAGONISM
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2125785B1

  公开（公告）日：2011-11-16
• US8143281B2
  申请人：——

  公开号：US8143281B2

  公开（公告）日：2012-03-27
• [EN] INDOLES<br/>[FR] INDOLES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2008080842A1

  公开（公告）日：2008-07-10

  [EN] The present invention is concerned with novel indol-3-yl-carbonyl-piperidine-benzopyrrolone, -benzoxazolone and -benzotriazole derivatives as V1a receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments. The active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases. In particular, the present invention is concerned with compounds of the general formula (I) wherein X, Y and R¹ to R¹⁰ are as described in the specification.
  [FR] Nouveaux dérivés d'indol-3-yl-carbonyl-pipéridine- benzopyrrolone, d'indol-3-yl-carbonyl-pipéridine-benzoxazolone et d'indol-3-yl-carbonyl-pipéridine-benzotriazole en tant qu'antagonistes du récepteur V1a, leur production, des compositions pharmaceutiques les contenant et leur utilisation en tant que médicaments. Les composés actifs selon la présente invention sont utiles pour prévenir et / ou traiter l'anxiété, les troubles dépressifs et d'autres maladies. En particulier, la présente invention concerne des composés de formule générale (I) dans laquelle X, Y et R¹ à R¹⁰ sont tels que définis dans le descriptif.