2,2-Dimethylpropanoyloxymethyl 8-[1-(2,2-dimethylpropanoyloxymethyl)-2-oxo-3-pyridyl]-4-fluoro-6-[(5-fluoro-2-methoxy-4-pyridyl)methyl]furo[2,3-e]indole-7-carboxylate | 1037762-29-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,2-Dimethylpropanoyloxymethyl 8-[1-(2,2-dimethylpropanoyloxymethyl)-2-oxo-3-pyridyl]-4-fluoro-6-[(5-fluoro-2-methoxy-4-pyridyl)methyl]furo[2,3-e]indole-7-carboxylate
• 英文别名: 2,2-dimethylpropanoyloxymethyl 8-[1-(2,2-dimethylpropanoyloxymethyl)-2-oxopyridin-3-yl]-4-fluoro-6-[(5-fluoro-2-methoxypyridin-4-yl)methyl]furo[2,3-e]indole-7-carboxylate
• CAS: 1037762-29-0
• 化学式: C₃₅H₃₅F₂N₃O₉
• 分子量: 679.674
• InChiKey: AFPUTOVDTQBQEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  49
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  139
• 氢给体数：
  0
• 氢受体数：
  12

文献信息

• 4,5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS
  申请人：Chen Kevin X.

  公开号：US20100098661A1

  公开（公告）日：2010-04-22

  The present invention relates to 4,5-ring annulated indole derivatives, compositions comprising at least one 4,5-ring annulated indole derivatives, and methods of using the 4,5-ring annulated indole derivatives for treating or preventing a viral infection or a virus-related disorder in a patient. Wherein ring Z, of formula (I), is a cyclopentyl, cyclopentenyl, 5-membered heterocycloalkyl, 5-membered heterocycloalkenyl or 5-membered heteroaryl ring.
• US8557848B2
  申请人：——

  公开号：US8557848B2

  公开（公告）日：2013-10-15