3-(2,3-dichloro-4-dimethylamino-phenyl)-acrylic acid | 845908-38-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-(2,3-dichloro-4-dimethylamino-phenyl)-acrylic acid
• 英文别名: (E)-3-[2,3-dichloro-4-(dimethylamino)phenyl]prop-2-enoic acid
• CAS: 845908-38-5
• 化学式: C₁₁H₁₁Cl₂NO₂
• 分子量: 260.12
• InChiKey: LOFSZEUQMILBIV-GQCTYLIASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF<br/>[FR] DERIVES D'ACRYLAMIDE SERVANT D'ANTAGONISTES DE L'INTEGRINE VLA-1, ET LEURS UTILISATIONS
  申请人：ICOS CORP

  公开号：WO2005016883A2

  公开（公告）日：2005-02-24

  Compounds that are VLA-1 integrin antagonists are disclosed. Also disclosed are compositions containing such compounds, and methods of using such compounds in treating diseases mediated, at least in part, by the VLA-1 integrin.
• [EN] COMBINATIONS COMPRISING ALPHA-2-DELTA LIGANDS AND NMDA RECEPTOR ANTAGONISTS<br/>[FR] COMBINAISONS COMPRENANT DES LIGANDS ALPHA-2-DELTA ET DES ANTAGONISTES DES RECEPTEURS DE NMDA
  申请人：PFIZER JAPAN INC

  公开号：WO2005102390A2

  公开（公告）日：2005-11-03

  The instant invention relates to a synergistic combination of an alpha-2-delta ligand and an NMDA, suitably NR2B, receptor antagonist, or pharmaceutically acceptable salts, esters or solvates thereof, pharmaceutical compositions thereof and their use in the treatment of pain, particularly neuropathic pain, and disorders of the central nervous system.