1-Methyl-2-<1-hydroxy-2-phenyl>-aethyl-imidazol | 91565-99-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-Methyl-2-<1-hydroxy-2-phenyl>-aethyl-imidazol
• 英文别名: 1-(1-methyl-1H-imidazol-2-yl)-2-phenyl-ethanol；1-(1-Methylimidazol-2-yl)-2-phenylethanol
• CAS: 91565-99-0
• 化学式: C₁₂H₁₄N₂O
• 分子量: 202.256
• InChiKey: XVMQYHDLOGLQCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Methyl-2-<1-hydroxy-2-phenyl>-aethyl-imidazol 、 苯 在 三氟甲磺酸 作用下， 以91%的产率得到2-(1,2-diphenylethyl)-1-methyl-1H-imidazole
  参考文献：
  名称：

  Superelectrophilic Chemistry of Imidazoles

  摘要：

  The mechanistic and synthetic chemistry of imidazole-based superelectrophiles has been studied. The protonated imidazole ring, or imidazolium group, is shown to enhance the electrophilic reactivity of an adjacent carboxonium group (compared to a related monocationic species). This leads to efficient condensation reactions between imidazole aldehydes and ketone with arenes in the Bronsted superacid CF3SO3H. The imidazole-based superelectrophiles are shown to be useful in other reactions leading to functionalized heterocycles. The imidazolium group may also trigger charge migration reactions in dicationic species.

  DOI：

  10.1021/jo802798x
• 作为产物：
  描述：

  1-甲基-1H-咪唑-2-甲醛 、 苄基氯化镁 生成 1-Methyl-2-<1-hydroxy-2-phenyl>-aethyl-imidazol
  参考文献：
  名称：

  Superelectrophilic Chemistry of Imidazoles

  摘要：

  The mechanistic and synthetic chemistry of imidazole-based superelectrophiles has been studied. The protonated imidazole ring, or imidazolium group, is shown to enhance the electrophilic reactivity of an adjacent carboxonium group (compared to a related monocationic species). This leads to efficient condensation reactions between imidazole aldehydes and ketone with arenes in the Bronsted superacid CF3SO3H. The imidazole-based superelectrophiles are shown to be useful in other reactions leading to functionalized heterocycles. The imidazolium group may also trigger charge migration reactions in dicationic species.

  DOI：

  10.1021/jo802798x

文献信息

• DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF ISOPRENOID BIOSYNTHESIS
  申请人：BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

  公开号：US20150175582A1

  公开（公告）日：2015-06-25

  Antibacterial IspF inhibitor compounds and compositions are described. Methods include administering described compounds and compositions to treat bacterial or parasitic infections and to inhibit or parasite or bacterial growth.

  本文描述了抗菌IspF抑制剂化合物和组合物。方法包括给予所述化合物和组合物以治疗细菌或寄生虫感染并抑制寄生虫或细菌的生长。
• DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF ISOPRENOID BIOSYNTHESIS (ISPF)
  申请人：BOARD OF TRUSTEES OF NORTHERN ILLINOIS UNIVERSITY

  公开号：US20160257655A1

  公开（公告）日：2016-09-08

  Antibacterial and antimalarial IspF inhibitor compounds and compositions are described. Methods include administering described compounds and compositions to treat bacterial or parasitic infections and to inhibit parasite or bacterial growth.

  本文描述了抗菌和抗疟疾的IspF抑制剂化合物和组合物。方法包括给予所述化合物和组合物以治疗细菌或寄生虫感染并抑制寄生虫或细菌的生长。
• US9309232B2
  申请人：——

  公开号：US9309232B2

  公开（公告）日：2016-04-12
• US9890126B2
  申请人：——

  公开号：US9890126B2

  公开（公告）日：2018-02-13
• [EN] DESIGN AND SYNTHESIS OF NOVEL INHIBITORS OF ISOPRENOID BIOSYNTHESIS<br/>[FR] CONCEPTION ET SYNTHÈSE D'INHIBITEURS INÉDITS DE LA BIOSYNTHÈSE DES ISOPRÉNOÏDES
  申请人：UNIV NORTHERN ILLINOIS

  公开号：WO2013163159A2

  公开（公告）日：2013-10-31

  Antibacterial IspF inhibitor compounds and compositions are described. Methods include administering described compounds and compositions to treat bacterial or parasitic infections and to inhibit or parasite or bacterial growth.