3-deoxy-3-((β-D-glucopyranosyl)sulfonylamino)-β-D-glucopyranose | 1287194-43-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-deoxy-3-((β-D-glucopyranosyl)sulfonylamino)-β-D-glucopyranose
• 英文别名: (2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-N-[(2R,3R,4S,5S,6R)-2,3,5-trihydroxy-6-(hydroxymethyl)oxan-4-yl]oxane-2-sulfonamide
• CAS: 1287194-43-7
• 化学式: C₁₂H₂₃NO₁₂S
• 分子量: 405.38
• InChiKey: SLNGEAHVDXVFPQ-FPIKPGRSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  235
• 氢给体数：
  9
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  3-deoxy-3-((2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)sulfonylamino)-α,β-D-glucopyranose 在 sodium methylate 作用下， 以 甲醇 为溶剂， 生成 3-deoxy-3-((β-D-glucopyranosyl)sulfonylamino)-β-D-glucopyranose 、 3-deoxy-3-((β-D-glucopyranosyl)sulfonylamino)-α-D-glucopyranose
  参考文献：
  名称：

  Synthesis of Sulfonamide-Bridged Glycomimetics

  摘要：

  A flexible and short synthesis of sulfonamide-bridged di-, tri-, tetra-, and octasaccharide glycomimetics was accomplished by reaction of glycosyl thioacetates with amino sugar substrates. The chemistry to incorporate the sulfonamide linker in place of a native O-glycosidic bond was broadly scoped, allowing access to head-to-head (1 <-> 1) and head-to-tail (1 -> 2), (1 -> 3), (1 -> 4), and (1 -> 6) sulfonamide-bridged glycomimetics. The synthesis proceeds with retention of configuration at the anomeric center and is compatible with variable stereochemical arrangements and with acid- and base-labile protecting groups.

  DOI：

  10.1021/jo2001269