N-((S)-1-((R)-1-(2-acetyl-9-cyclopropyl-6-fluoro-3-hydroxy-8-methoxy-4-oxo-4,9-dihydrothieno[2,3-b]quinolin-7-yl)pyrrolidin-3-yl)ethyl)acetamide | 1445534-60-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-((S)-1-((R)-1-(2-acetyl-9-cyclopropyl-6-fluoro-3-hydroxy-8-methoxy-4-oxo-4,9-dihydrothieno[2,3-b]quinolin-7-yl)pyrrolidin-3-yl)ethyl)acetamide
• 英文别名: N-[(1S)-1-[(3R)-1-(2-acetyl-9-cyclopropyl-6-fluoro-3-hydroxy-8-methoxy-4-oxothieno[2,3-b]quinolin-7-yl)pyrrolidin-3-yl]ethyl]acetamide
• CAS: 1445534-60-0
• 化学式: C₂₅H₂₈FN₃O₅S
• 分子量: 501.579
• InChiKey: APLGXEGADFHBEH-SMDDNHRTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  35
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  127
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• 2-SUBSTITUTED-THIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS
  申请人：Phadke Avinash

  公开号：US20130165471A1

  公开（公告）日：2013-06-27

  Disclosed herein are 2-substituted-thienoquinolones and related compounds and their pharmaceutically acceptable salts useful as antiviral agents and having the general formula in which the variables R 2 , R 3 , and R 7 are defined herein. Certain compounds provided herein possess potent antibacterial, antiprotozoal, or antifungal activity and are particularly efficacious for the treatment of MRSA infections. The invention also provides pharmaceutical compositions, pharmaceutical compositions containing a 2-substituted-thienoquinolone in combination with one or more other active agent, and methods of treating microbial infections in animals by administering an effective amount of a 2-substituted-thienoquinolone to an animal suffering from a microbial infection.

  本文公开了2-取代噻吩喹啉及相关化合物和其药学上可接受的盐，作为抗病毒剂，并具有以下一般式中定义的变量R2，R3和R7。本文提供的某些化合物具有强大的抗菌、抗原虫或抗真菌活性，特别适用于治疗MRSA感染。本发明还提供了制药组合物，其中包含2-取代噻吩喹啉与一种或多种其他活性剂的组合物，以及通过向患有微生物感染的动物施用有效量的2-取代噻吩喹啉来治疗动物的微生物感染的方法。
• [EN] 2-SUBSTITUTED-THIENOQUINOLONES AND RELATED COMPOUNDS AS ANTI-INFECTIVE AGENTS<br/>[FR] THIÉNOQUINOLONES SUBSTITUÉES EN POSITION 2 ET COMPOSÉS APPARENTÉS COMME AGENTS ANTI-INFECTIEUX
  申请人：ACHILLION PHARMACEUTICALS INC

  公开号：WO2013096785A1

  公开（公告）日：2013-06-27

  Disclosed herein are 2-substituted-thienoquinolones and related compounds and their pharmaceutically acceptable salts useful as antiviral agents and having the general formula in which the variables R2, R3, and R7 are defined herein. Certain compounds provided herein possess potent antibacterial, antiprotozoal, or antifungal activity and are particularly efficacious for the treatment of MRSA infections. The invention also provides pharmaceutical compositions, pharmaceutical compositions containing a 2-substituted-thienoquinolone in combination with one or more other active agent, and methods of treating microbial infections in animals by administering an effective amount of a 2-substituted-thienoquinolone to an animal suffering from a microbial infection.