5-bromo-3-[5-(4-methylphenyl)-4-phenyl-1H-imidazol-2-yl]-1H-indole | 1235969-94-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-bromo-3-[5-(4-methylphenyl)-4-phenyl-1H-imidazol-2-yl]-1H-indole
• CAS: 1235969-94-4
• 化学式: C₂₄H₁₈BrN₃
• 分子量: 428.331
• InChiKey: MJDBYMNDZZKKCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  28
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  44.5
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5-溴吲哚-3-甲醛 、 1-(4-甲基苯基)-2-苯基乙烷-1,2-二酮 在 ammonium acetate 、 溶剂黄146 作用下， 以100%的产率得到5-bromo-3-[5-(4-methylphenyl)-4-phenyl-1H-imidazol-2-yl]-1H-indole
  参考文献：
  名称：

  Potent antimicrobial activity of 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus

  摘要：

  A new series of antimicrobial derivatives [3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole)] have been synthesized with potent activity against strains of Staphylococcus aureus, including methicillin-resistant strains (MRSA). Compound 17 [3-(4,5-bis(4-fluorophenyl)-1H-imidazol-2-yl)-5-bromo-1H-indole], the most active derivative was shown to inhibit the growth of all Gram-positive strains tested, including vancomycin resistant Enterococcus faecalis and Enterococcus faecium with no activity against Gram-negative bacteria. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.137

文献信息

• Potent antimicrobial activity of 3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus
  作者：Raed A. Al-Qawasmeh、Mario Huesca、Venkata Nedunuri、Robert Peralta、Jim Wright、Yoon Lee、Aiping Young

  DOI：10.1016/j.bmcl.2010.04.137

  日期：2010.6

  A new series of antimicrobial derivatives [3-(4,5-diaryl-1H-imidazol-2-yl)-1H-indole)] have been synthesized with potent activity against strains of Staphylococcus aureus, including methicillin-resistant strains (MRSA). Compound 17 [3-(4,5-bis(4-fluorophenyl)-1H-imidazol-2-yl)-5-bromo-1H-indole], the most active derivative was shown to inhibit the growth of all Gram-positive strains tested, including vancomycin resistant Enterococcus faecalis and Enterococcus faecium with no activity against Gram-negative bacteria. (C) 2010 Elsevier Ltd. All rights reserved.