6-(4-bromophenyl)-2-(6-methylbenzofuran-3-ylmethyl)-imidazo[2,1-b][1,3,4]thiadiazole-5-carbonitrile | 1061271-26-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6-(4-bromophenyl)-2-(6-methylbenzofuran-3-ylmethyl)-imidazo[2,1-b][1,3,4]thiadiazole-5-carbonitrile
• CAS: 1061271-26-8
• 化学式: C₂₁H₁₃BrN₄OS
• 分子量: 449.33
• InChiKey: UAKFTCJHRMUYRK-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  6-(4-bromophenyl)-2-(6-methylbenzofuran-3-ylmethyl)-imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde oxime 在 乙酸酐 作用下， 反应 1.0h， 以68%的产率得到6-(4-bromophenyl)-2-(6-methylbenzofuran-3-ylmethyl)-imidazo[2,1-b][1,3,4]thiadiazole-5-carbonitrile
  参考文献：
  名称：

  Synthesis and anti-inflammatory evaluation of methylene bridged benzofuranyl imidazo[2,1-b][1,3,4]thiadiazoles

  摘要：

  A series of 6-substituted and 5,6-disubstituted 2-(6-methyl-benzofuran-3-ylmethyl)-imidazo[2,1-b] [ 1,3,4]thiadiazoles have been synthesized. The new compounds have been tested for their in vivo analgesic, anti-inflammatory activities. Qualitative SAR studies indicate that the chloro substitution in the imidazole ring and introduction of formyl group at C-5 position of the imidazole ring increased the anti-inflammatory and analgesic activity. All the newly synthesized compounds have been characterized by spectral data and ORTEP diagram of one of the intermediates 6-(4-chlorophenyl)-2-(6-methyl-benzofuran-3-ylmethyl)-5-morpholin-4-ylmethyl imidazo[2,1-b][1,3,4]thiadiazole is reported herein. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.06.023