4-nitrophenyl 6-azido-6-deoxy-α-D-galactopyranoside | 1295584-15-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-nitrophenyl 6-azido-6-deoxy-α-D-galactopyranoside
• 英文别名: (2R,3R,4S,5R,6R)-2-(azidomethyl)-6-(4-nitrophenoxy)oxane-3,4,5-triol
• CAS: 1295584-15-4
• 化学式: C₁₂H₁₄N₄O₇
• 分子量: 326.266
• InChiKey: REENPGLKLWWHDH-IIRVCBMXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  139
• 氢给体数：
  3
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  p-Nitrophenyl 2,3,4-tri-O-acetyl-6-azido-6-deoxy-alpha-D-galactopyranoside 在 甲醇 、 sodium methylate 作用下， 以0.056 g的产率得到4-nitrophenyl 6-azido-6-deoxy-α-D-galactopyranoside
  参考文献：
  名称：

  Activity of Debaryomyces hansenii UFV-1 α-galactosidases against α-d-galactopyranoside derivatives

  摘要：

  alpha-D-Galactopyranosides were synthesized and their inhibitory activities toward the Debatyomyces hansenil UFV-1 extracellular and intracellular alpha-galactosidases were evaluated. Methyl alpha-D-galactopyranoside was the most potent inhibitor compared to the others tested, with K'(i) values of 0.82 and 1.12 mmol L-1, for extracellular and intracellular enzymes, respectively. These results indicate that the presence of a hydroxyl group in the C-6 position of alpha-D-galactopyranoside derivatives is important for the recognition by D. hansenii UFV-1 alpha-galactosidases. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2011.01.024