(10aZ)-5,6,6a,7,9,10-hexahydro-1-methyl-3-(trimethylsilyl)benzo[e]azulene-2,8(1H,4H)-dione 8-monoethylene ketal | 1037668-36-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (10aZ)-5,6,6a,7,9,10-hexahydro-1-methyl-3-(trimethylsilyl)benzo[e]azulene-2,8(1H,4H)-dione 8-monoethylene ketal
• 英文别名: 1'-Methyl-3'-trimethylsilylspiro[1,3-dioxolane-2,8'-1,4,5,6,6a,7,9,10-octahydrobenzo[e]azulene]-2'-one
• CAS: 1037668-36-2
• 化学式: C₂₀H₃₀O₃Si
• 分子量: 346.542
• InChiKey: YTADXYABUSEDAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-(5-(trimethylsilyl)pent-4-ynyl)-4-(prop-1-enylidene)cyclohexanone monoethylene ketal 、 一氧化碳 在 di(rhodium)tetracarbonyl dichloride 作用下， 以 甲苯 为溶剂， 反应 22.0h， 以87%的产率得到(10aZ)-5,6,6a,7,9,10-hexahydro-1-methyl-3-(trimethylsilyl)benzo[e]azulene-2,8(1H,4H)-dione 8-monoethylene ketal
  参考文献：
  名称：

  A General Synthetic Route to Differentially Functionalized Angularly and Linearly Fused [6−7−5] Ring Systems: A Rh(I)-Catalyzed Cyclocarbonylation Reaction

  摘要：

  Investigations of a Rh(I)-catalyzed cyclocarbonylation reaction reveal its general synthetic utility for accessing highly functionalized tricyclic [6-7-5] linear and angular ring systems from allene-ynes. Three types of allene-ynes were prepared and subjected to Rh(I)-catalyzed cyclocarbonylation conditions. For three series of allene-ynes, the [6-7-5] ring systems were afforded in varying yields depending on the substrate structure. One series of allene-ynes afforded the [6-6-5] ring system possessing an alpha-alkylidene cyclopentenone as a result of a selective reaction with the proximal double bond of the allene.

  DOI：

  10.1021/jo8007258