Ethyl 2-(8-hydroxyquinolin-5-yl)-8,9-dimethoxy-3-methyl-5,6-dihydropyrrolo[2,1-a]isoquinoline-1-carboxylate | 497961-64-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Ethyl 2-(8-hydroxyquinolin-5-yl)-8,9-dimethoxy-3-methyl-5,6-dihydropyrrolo[2,1-a]isoquinoline-1-carboxylate
• CAS: 497961-64-5
• 化学式: C₂₇H₂₆N₂O₅
• 分子量: 458.514
• InChiKey: KILMQYUASQYHIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  82.8
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• DIEBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10
  申请人：Gopalan Balasubramanian

  公开号：US20090281131A1

  公开（公告）日：2009-11-12

  The present invention relates to novel heterocyclic compounds that are useful as phosphodiesterase inhibitors (PDEs) in particular phosphodiesterase type 4 (PDE IV) inhibitors and phosphodiesterase type 10 (PDE 10) inhibitors, processes for their preparation, pharmaceutical compositions containing them and their use in treating allergic and inflammatory diseases as well as for inhibiting the production of Tumor Necrosis Factor (TNF-α).

  本发明涉及一种新型杂环化合物，其作为磷酸二酯酶抑制剂（PDEs），特别是磷酸二酯酶4型（PDE IV）抑制剂和磷酸二酯酶10型（PDE 10）抑制剂，其制备方法，含有它们的制药组合物以及它们在治疗过敏和炎症性疾病以及抑制肿瘤坏死因子（TNF-α）的产生中的用途。
• Methods for treating diabetes and related disorders using pde10a inhibitors
  申请人：Sweet Laurel

  公开号：US20070032404A1

  公开（公告）日：2007-02-08

  The methods of the invention relate to the treatment of diabetes, including type 2 diabetes, and related disorders by administration of a PDE10A inhibitor. Such PDE10A inhibitors may be administered in conjunction with alpha-glucosidase inhibitors, insulin sensitizers, insulin secretagogues, hepatic glucose output lowering compounds, B-3 agonist, or insulin. Such PDE10A inhibitors may also be administered in conjunction with body weight reducing agents. Further methods of the invention relate to stimulating insulin release from pancreatic cells, for example, in response to an elevation in blood glucose concentration, by administration of a PDE10A inhibitor.
• US8263648B2
  申请人：——

  公开号：US8263648B2

  公开（公告）日：2012-09-11