Methanesulfonic acid (2R,3R,3aS,9aS)-5,5,7,7-tetraisopropyl-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester | 433934-28-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Methanesulfonic acid (2R,3R,3aS,9aS)-5,5,7,7-tetraisopropyl-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester
• CAS: 433934-28-2
• 化学式: C₂₃H₄₂N₂O₉SSi₂
• 分子量: 578.831
• InChiKey: QFWYVINXVQMHBB-ITTUMRLJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.04
• 重原子数：
  37.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  135.15
• 氢给体数：
  1.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  Methanesulfonic acid (2R,3R,3aS,9aS)-5,5,7,7-tetraisopropyl-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成 1-((2R,3S,3aR,9aS)-3-Hydroxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-5-methyl-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  α-l-RNA (α-l-ribo Configured RNA): Synthesis and RNA-Selective Hybridization of α-l-RNA/α-l-LNA Chimera

  摘要：

  Synthesis of the novel a-L-ribofuranosyl phosphoramidite derivative 7 was accomplished via the alpha-L-ribofuranosyl thymine nucleoside 4. Amidite 7 was used in automated syntheses of chimeric oligonucleotides composed of mixtures of the novel alpha-L-RNA nucleotide monomer (T-alphaL, alpha-L-ribo configured RNA), and DNA, LNA (T-L, locked nucleic acid) or alpha-L-LNA (T-alphaL(T), alpha-L-ribo configured locked nucleic acid) nucleotide monomers. For alpha-L-RNA/DNA and alpha-L-RNA/alpha-L-LNA chimeras, RNA-selective hybridization was obtained, for alpha-L-RNA/alpha-L-LNA chimera we found increased binding affinity compared to the corresponding DNA:RNA reference duplex. In addition, alpha-L-RNA/alpha-L-LNA chimera displayed significant stabilization towards 3'-exonucleolytic degradation. These, results indicate that alpha-L-RNA/alpha-L-LNA chimeras deserve further evaluation as antisense molecules. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00807-1
• 作为产物：
  描述：

  甲基磺酰氯 、 1-<3',5'-O-(1,1,3,3-Tetraisopropyldisiloxane-1,3-diyl)-α-L-arabinofuranosyl>thymine 在 吡啶 作用下， 以84%的产率得到Methanesulfonic acid (2R,3R,3aS,9aS)-5,5,7,7-tetraisopropyl-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester
  参考文献：
  名称：

  α-l-RNA (α-l-ribo Configured RNA): Synthesis and RNA-Selective Hybridization of α-l-RNA/α-l-LNA Chimera

  摘要：

  Synthesis of the novel a-L-ribofuranosyl phosphoramidite derivative 7 was accomplished via the alpha-L-ribofuranosyl thymine nucleoside 4. Amidite 7 was used in automated syntheses of chimeric oligonucleotides composed of mixtures of the novel alpha-L-RNA nucleotide monomer (T-alphaL, alpha-L-ribo configured RNA), and DNA, LNA (T-L, locked nucleic acid) or alpha-L-LNA (T-alphaL(T), alpha-L-ribo configured locked nucleic acid) nucleotide monomers. For alpha-L-RNA/DNA and alpha-L-RNA/alpha-L-LNA chimeras, RNA-selective hybridization was obtained, for alpha-L-RNA/alpha-L-LNA chimera we found increased binding affinity compared to the corresponding DNA:RNA reference duplex. In addition, alpha-L-RNA/alpha-L-LNA chimera displayed significant stabilization towards 3'-exonucleolytic degradation. These, results indicate that alpha-L-RNA/alpha-L-LNA chimeras deserve further evaluation as antisense molecules. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00807-1