(6-(hydroxymethyl)-4,5,6,7-tetrahydroazepino[3,2, 1-hi] indol-1-yl)oxoacetic acid methyl ester | 345264-81-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (6-(hydroxymethyl)-4,5,6,7-tetrahydroazepino[3,2, 1-hi] indol-1-yl)oxoacetic acid methyl ester
• 英文别名: Methyl 2-[10-(hydroxymethyl)-1-azatricyclo[6.4.1.04,13]trideca-2,4,6,8(13)-tetraen-3-yl]-2-oxoacetate
• CAS: 345264-81-5
• 化学式: C₁₆H₁₇NO₄
• 分子量: 287.315
• InChiKey: OUHFVEQRUJWRPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  68.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-吲哚乙酰胺 、 (6-(hydroxymethyl)-4,5,6,7-tetrahydroazepino[3,2, 1-hi] indol-1-yl)oxoacetic acid methyl ester 在 potassium tert-butylate 、 盐酸 作用下， 以 四氢呋喃 为溶剂， 生成 3-(6-hydroxymethyl-4,5,6,7-tetrahydroazepino[3,2,1-hi]indol-1-yl)-4-(1H-indol-3-yl)pyrrole-2,5-dione
  参考文献：
  名称：

  Synthesis of 1,7-annulated indoles and their applications in the studies of cyclin dependent kinase inhibitors

  摘要：

  The synthesis of a novel series of 1,7-annulated indolocarbazoles 2 and 16 is described. These compounds were found to be potent cyclin dependent kinase inhibitors with good antiproliferative activity against two human carcinoma cell lines. These inhibitors also arrested tumor cells at the G1 phase and inhibited pRb phosphorylation. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.033
• 作为产物：
  描述：

  4,5-Dihydro-azepino[3,2,1-hi]indole-6-carboxylic acid methyl ester 在 palladium on activated charcoal lithium aluminium tetrahydride 、 氢气 作用下， 以 四氢呋喃 、 甲醇 、 乙醚 、 乙酸乙酯 为溶剂， 生成 (6-(hydroxymethyl)-4,5,6,7-tetrahydroazepino[3,2, 1-hi] indol-1-yl)oxoacetic acid methyl ester
  参考文献：
  名称：

  Synthesis of 1,7-annulated indoles and their applications in the studies of cyclin dependent kinase inhibitors

  摘要：

  The synthesis of a novel series of 1,7-annulated indolocarbazoles 2 and 16 is described. These compounds were found to be potent cyclin dependent kinase inhibitors with good antiproliferative activity against two human carcinoma cell lines. These inhibitors also arrested tumor cells at the G1 phase and inhibited pRb phosphorylation. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.033

文献信息

• Agents and methods for the treatment of proliferative diseases
  申请人：——

  公开号：US20030229026A1

  公开（公告）日：2003-12-11

  The present invention provides selective kinase inhibitors of formula (I). 1

  这项发明提供了式（I）的选择性激酶抑制剂。
• Agents and method for the treatment of proliferative diseases
  申请人：——

  公开号：US20030092676A1

  公开（公告）日：2003-05-15

  1 The present invention provides selective kinase inhibitors of formula (I).

  本发明提供了式(I)的选择性激酶抑制剂。
• S,s' -bis-(alpha, alpha' - disubstituted - alpha" - acetic acid) - trithiocarbonates and polymers thereof for toughening thermosetting resins
  申请人：——

  公开号：US20030187138A1

  公开（公告）日：2003-10-02

  A toughener comprising a trithiocarbonate polymer having an epoxy end group is described which is utilized with various thermosettable polymers such as epoxy, polyurethane, and the like. A toughened composition is made by curing the thermosettable polymer and the toughener utilizing various curing agents.

  描述了一种由具有环氧端基的三硫代碳酸酯聚合物组成的增韧剂，它可与各种热固性聚合物（如环氧树脂、聚氨酯等）一起使用。通过使用各种固化剂固化热固性聚合物和增韧剂，可制成增韧组合物。
• EPOXY RESIN SYSTEMS MODIFIED WITH LOW VISCOSITY STATISTICAL MONOFUNCTIONAL REACTIVE POLYMERS
  申请人：The B.F. Goodrich Company

  公开号：EP0526575A1

  公开（公告）日：1993-02-10
• AGENTS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES
  申请人：ELI LILLY AND COMPANY

  公开号：EP1242420A2

  公开（公告）日：2002-09-25