tert-butyl methyl(1-(((5-vinylpyridin-3-yl)oxy)methyl)cyclopropyl)carbamate | 959865-36-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tert-butyl methyl(1-(((5-vinylpyridin-3-yl)oxy)methyl)cyclopropyl)carbamate
• CAS: 959865-36-2
• 化学式: C₁₇H₂₄N₂O₃
• 分子量: 304.389
• InChiKey: ZTSNFHUOOFKDSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  51.66
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  tert-butyl methyl(1-(((5-vinylpyridin-3-yl)oxy)methyl)cyclopropyl)carbamate 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 以65%的产率得到N-methyl-1-((5-vinylpyridin-3-yloxy)methyl)cyclopropanamine hydrochloride
  参考文献：
  名称：

  Preparation and affinity profile of novel nicotinic ligands

  摘要：

  Novel nicotinic ligands, characterized by the presence of an amino substituted cyclopropane ring connected to a pyridine nucleus, are described. Pharmacological investigation revealed that these compounds exhibit highest affinity for the rat alpha 4 beta 2 subtype of the nicotinic receptor with no affinity for the muscarinic receptor. No appreciable affinity for the muscular or for the ganglionic nicotinic receptor was observed at concentrations up to 10 mu M. The increase in cortical ACh release as well as a positive effect on memory in a social recognition test in rat are exemplified. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.075
• 作为产物：
  描述：

  tert-butyl 1-([(5-bromopyridin-3-yl)oxy]methyl)cyclopropyl(methyl)carbamate 、 三丁基乙烯基锡 在 四(三苯基膦)钯 作用下， 以 甲苯 为溶剂， 以80%的产率得到tert-butyl methyl(1-(((5-vinylpyridin-3-yl)oxy)methyl)cyclopropyl)carbamate
  参考文献：
  名称：

  Preparation and affinity profile of novel nicotinic ligands

  摘要：

  Novel nicotinic ligands, characterized by the presence of an amino substituted cyclopropane ring connected to a pyridine nucleus, are described. Pharmacological investigation revealed that these compounds exhibit highest affinity for the rat alpha 4 beta 2 subtype of the nicotinic receptor with no affinity for the muscarinic receptor. No appreciable affinity for the muscular or for the ganglionic nicotinic receptor was observed at concentrations up to 10 mu M. The increase in cortical ACh release as well as a positive effect on memory in a social recognition test in rat are exemplified. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.075