2-(4-Methylquinolin-6-yl)-[1,3]oxazolo[4,5-b]pyridine | 142330-74-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(4-Methylquinolin-6-yl)-[1,3]oxazolo[4,5-b]pyridine
• CAS: 142330-74-3
• 化学式: C₁₆H₁₁N₃O
• 分子量: 261.283
• InChiKey: HGFBHUOOTPLAOI-UHFFFAOYSA-N

物化性质

• 沸点：
  435.3±30.0 °C(Predicted)
• 密度：
  1.295±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氨基-3-羟基吡啶 、 4-甲基-6-喹啉羧酸 在 磷酸酐 作用下， 反应 2.0h， 生成 2-(4-Methylquinolin-6-yl)-[1,3]oxazolo[4,5-b]pyridine
  参考文献：
  名称：

  Savarino, Piero; Viscardi, Guido; Barni, Ermanno, Journal of Heterocyclic Chemistry, 1992, vol. 29, # 1, p. 185 - 192

  摘要：

  DOI：

文献信息

• Method for optical measurement of multi-stranded nucleic acid
  申请人：Nakamura Kouki

  公开号：US20050112770A1

  公开（公告）日：2005-05-26

  A method for optical measurement of a multi-stranded nucleic acid which comprises the step of bringing a compound into contact with a multi-stranded nucleic acid wherein said compound is capable of interacting with the multi-stranded nucleic acid, wherein the compound has the following properties: (a) the compound can exist in a substantially colorless and non-fluorescent state under at least one condition in an aqueous solution in the absence of the multi-stranded nucleic acid, and (b) when the multi-stranded nucleic acid is allowed to exist in the condition defined in the above (a), the compound changes to a substantially colored state based on an interaction with the multi-stranded nucleic acid and substantially expresses fluorescent property based on said interaction.

  一种用于多股核酸的光学测量方法，包括以下步骤：将一种化合物与多股核酸接触，所述化合物能够与多股核酸相互作用，且该化合物具有以下性质：(a) 在无多股核酸的情况下，该化合物能够在水溶液中在至少一种条件下处于基本无色和非荧光状态，(b) 当多股核酸存在于上述(a)定义的状态下时，该化合物会因与多股核酸的相互作用而转变为基本上有色的状态，并基于该相互作用而表现出基本上荧光的性质。
• METHOD FOR OPTICAL MEASUREMENT OF MULTI-STRANDED NUCLEIC ACID
  申请人：NAKAMURA Kouki

  公开号：US20080124732A1

  公开（公告）日：2008-05-29

  A method for optical measurement of a multi-stranded nucleic acid which comprises the step of bringing a compound into contact with a multi-stranded nucleic acid wherein said compound is capable of interacting with the multi-stranded nucleic acid, wherein the compound has the following properties: (a) the compound can exist in a substantially colorless and non-fluorescent state under at least one condition in an aqueous solution in the absence of the multi-stranded nucleic acid, and (b) when the multi-stranded nucleic acid is allowed to exist in the condition defined in the above (a), the compound changes to a substantially colored state based on an interaction with the multi-stranded nucleic acid and substantially expresses fluorescent property based on said interaction.

  一种用于光学测量多股核酸的方法，包括以下步骤：将一种化合物与多股核酸接触，其中该化合物能够与多股核酸相互作用，该化合物具有以下特性：（a）在无多股核酸存在的情况下，在水溶液中至少有一个条件下，该化合物可以存在于基本无色且不发荧光的状态；（b）当多股核酸被允许在上述（a）所定义的条件下存在时，该化合物会因与多股核酸的相互作用而转变为基本上带色的状态，并基于该相互作用表现出基本上发荧光的特性。
• Method for optical measurement of multi-stranded nucleic acid using cyanine dyes
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP1362894A2

  公开（公告）日：2003-11-19

  A method for optical measurement of a multi-stranded nucleic acid which comprises the step of bringing a compound into contact with a multi-stranded nucleic acid wherein said compound is capable of interacting with the multi-stranded nucleic acid, wherein the compound has the following properties: (a) the compound can exist in a substantially colorless and non-fluorescent state under at least one condition in an aqueous solution in the absence of the multi-stranded nucleic acid, and (b) when the multi-stranded nucleic acid is allowed to exist in the condition defined in the above (a), the compound changes to a substantially colored state based on an interaction with the multi-stranded nucleic acid and substantially expresses fluorescent property based on said interaction.

  一种光学测量多链核酸的方法，包括使化合物与多链核酸接触的步骤，其中所述化合物能够与多链核酸相互作用，所述化合物具有以下特性： (a) 在没有多链核酸的情况下，该化合物在水溶液中的至少一种条件下能以基本无色和无荧光的状态存在，以及 (b) 当允许多链核酸在上述(a)中定义的条件下存在时，基于与多链核酸的相互作用，该复 合物转变为基本上有色的状态，并基于所述相互作用基本上表现出荧光特性。
• Savarino, Piero; Viscardi, Guido; Barni, Ermanno, Journal of Heterocyclic Chemistry, 1992, vol. 29, # 1, p. 185 - 192
  作者：Savarino, Piero、Viscardi, Guido、Barni, Ermanno、Modica, Gaetano Di、Montoneri, Enzo、Quagliotto, Pierluigi

  DOI：——

  日期：——