(Z)-ethyl 2-(4-(2-nitrophenyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-ylidene)acetate | 1533410-57-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: (Z)-ethyl 2-(4-(2-nitrophenyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-ylidene)acetate
• CAS: 1533410-57-9
• 化学式: C₁₉H₁₉N₃O₄
• 分子量: 353.378
• InChiKey: HTJWXXGEBRGFRO-SEYXRHQNSA-N

反应信息

• 作为产物：
  描述：

  乙酰乙酸乙酯 、 邻苯二胺 、 邻硝基苯甲醛 在 溴化二甲基溴化锍 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 5.25h， 以65%的产率得到(Z)-ethyl 2-(4-(2-nitrophenyl)-4,5-dihydro-1H-benzo[b][1,4]diazepin-2(3H)-ylidene)acetate
  参考文献：
  名称：

  Bromodimethylsulfonium Bromide (BDMS)-Catalyzed Synthesis of 1,5-Benzodiazepines Using a Multi-Component Reaction Strategy

  摘要：

  A new approach for the synthesis of multi-functionalized 1,5-benzodiazepines is developed starting from o-phenylenediamines, -keto esters and aromatic aldehydes utilizing a one-pot, three-component strategy employing bromodimethylsulfonium bromide as the catalyst. The simple reaction procedure, good yields, mild reaction conditions and applicability to a wide range of substrates are some of the salient features of this protocol.

  DOI：

  10.1055/s-0033-1338984