N-(7(9)H-purin-6-yl)-β-D-ribofuranosylamine | 58538-07-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(7(9)H-purin-6-yl)-β-D-ribofuranosylamine
• CAS: 58538-07-1
• 化学式: C₁₀H₁₃N₅O₄
• 分子量: 267.244
• InChiKey: HHPJFLZSCWTSGY-KQYNXXCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  19.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  136.41
• 氢给体数：
  5.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  N-(7(9)H-purin-6-yl)-β-D-ribofuranosylamine 在 磷酸三甲酯 、 L-赖氨酸 、 Escherichia coli pyrophosphatase 、 Methylendiphosphoniumsaeure-tetranatriumsalz 、 magnesium chloride 、 zinc(II) chloride 作用下， 以 aq. buffer 为溶剂， 反应 0.17h， 生成
  参考文献：
  名称：

  Syntheses of stable, synthetic diadenosine polyphosphate analogues using recombinant histidine-tagged lysyl tRNA synthetase (LysU)

  摘要：

  Recombinant Escherichia coli lysyl-tRNA synthase (LysU) has been previously utilised in the production of stabile, synthetic diadenosine polyphosphate (ApnA) analogues. Here we report on the extended use of a new recombinant histidine residue-tagged LysU as a tool for highly controlled phosphateAphosphate bond formation between nucleotides, avoiding the need for complex protecting group chemistries. Resulting high yielding tandem LysU-based biosynthetic-synthetic/synthetic-biosynthetic strategies emerge for the preparation of varieties of ApnA analogues directly from inexpensive natural nucleotides and nucleosides. Analogues so formed make a useful small library with which to probe ApnA activities in vitro and in vivo leading to the discovery of new, potentially potent biopharmaceuticals active against chronic pain and other chronic, high-burden disease states. (C) 2014 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2014.03.064