2-(trimethylsilyl)ethyl 6-O-phosphocholine-β-D-galactopyranosyl-(1->6)-β-D-galactopyranosyl-(1->6)-β-D-galactopyranoside | 1063697-92-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(trimethylsilyl)ethyl 6-O-phosphocholine-β-D-galactopyranosyl-(1->6)-β-D-galactopyranosyl-(1->6)-β-D-galactopyranoside
• CAS: 1063697-92-6
• 化学式: C₂₈H₅₆NO₁₉PSi
• 分子量: 769.807
• InChiKey: JJERBUPBKIFRLX-LSZOJGAPSA-N

反应信息

• 作为产物：
  描述：

  2-(trimethylsilyl)ethyl 2,3,4-tri-O-benzoyl-6-O-phosphocholine-β-D-galactopyranosyl-(1->6)-2,3,4-tri-O-benzoyl-β-D-galactopyranosyl-(1->6)-2,3,4-tri-O-benzoyl-β-D-galactopyranosid 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以69%的产率得到2-(trimethylsilyl)ethyl 6-O-phosphocholine-β-D-galactopyranosyl-(1->6)-β-D-galactopyranosyl-(1->6)-β-D-galactopyranoside
  参考文献：
  名称：

  Synthetic studies on glycosphingolipids from Protostomia phyla: syntheses and biological activities of amphoteric glycolipids containing a phosphocholine residue from the earthworm Pheretima hilgendorfi

  摘要：

  Two types of amphoteric glycosphingolipid found in the earthworm Pheretima hilgendorfi, PC(-> 6)-beta-D-Galp-(1 -> 6)-beta-D-Galp-(1 -> 1)Cer (1) and PC(-> 6)-beta-D-Galp-(1 -> 6)-beta-D-Galp-(1 -> 6)-beta-D-Galp-(1 -> 1)Cer (2), and their derivatives (4, 5) were synthesized. These were examined for their ability to enhance production of interleukin-8 (IL-8), a potent inflammatory cytokine involved in neutrophil chemotaxis, in a TNF alpha-stimulated granulocytic HL-60 cells. Compounds 1 and 2 were found to be potent enhancers of IL-8 production. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2008.05.001