5,11,17,23-tetra-tert-butyl-25,27-bis[[4-(acridin-9-ylamino)butyl]oxy]-26,28-dipropoxy-calix[4]arene | 1224621-60-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5,11,17,23-tetra-tert-butyl-25,27-bis[[4-(acridin-9-ylamino)butyl]oxy]-26,28-dipropoxy-calix[4]arene
• 英文别名: N-[4-[[27-[4-(acridin-9-ylamino)butoxy]-5,11,17,23-tetratert-butyl-26,28-dipropoxy-25-pentacyclo[19.3.1.13,7.19,13.115,19]octacosa-1(24),3,5,7(28),9,11,13(27),15(26),16,18,21(25),22-dodecaenyl]oxy]butyl]acridin-9-amine
• CAS: 1224621-60-6
• 化学式: C₈₄H₁₀₀N₄O₄
• 分子量: 1229.74
• InChiKey: OFGNXLQXGXGPET-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  24
• 重原子数：
  92
• 可旋转键数：
  24
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  86.8
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  9-氯吖啶 、 5,11,17,23-Tetra-p-tert-butyl-25,27-bis<(aminobutyl)oxy>-26,28-dipropoxycalix<4>arene 在 苯酚 作用下， 反应 19.0h， 以48%的产率得到5,11,17,23-tetra-tert-butyl-25,27-bis[[4-(acridin-9-ylamino)butyl]oxy]-26,28-dipropoxy-calix[4]arene
  参考文献：
  名称：

  Interaction of acridine-calix[4]arene with DNA at the electrified liquid|liquid interface

  摘要：

  The behaviour of an acridine-functionalised calix[4]arene at the interface between two immiscible electrolyte solutions (ITIES) is reported. Molecular modelling showed that the acridine-calix[4]arene has regions of significant net positive charge spread throughout the protonated acridine moieties, consistent with it being able to function as an anion ionophore. The presence of this compound in the organic phase facilitated the transfer of aqueous phase electrolyte ions. Upon addition of double stranded DNA to the aqueous phase, the transfer of electrolyte anions was diminished, due to DNA binding to the acridine moiety at the ITIES. The behaviour provides a basis for DNA hybridization detection using electrochemistry at the ITIES. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.electacta.2010.01.042

文献信息

• Interaction of acridine-calix[4]arene with DNA at the electrified liquid|liquid interface
  作者：Francine Kivlehan、Myriam Lefoix、Humphrey A. Moynihan、Damien Thompson、Vladimir I. Ogurtsov、Grégoire Herzog、Damien W.M. Arrigan

  DOI：10.1016/j.electacta.2010.01.042

  日期：2010.3

  The behaviour of an acridine-functionalised calix[4]arene at the interface between two immiscible electrolyte solutions (ITIES) is reported. Molecular modelling showed that the acridine-calix[4]arene has regions of significant net positive charge spread throughout the protonated acridine moieties, consistent with it being able to function as an anion ionophore. The presence of this compound in the organic phase facilitated the transfer of aqueous phase electrolyte ions. Upon addition of double stranded DNA to the aqueous phase, the transfer of electrolyte anions was diminished, due to DNA binding to the acridine moiety at the ITIES. The behaviour provides a basis for DNA hybridization detection using electrochemistry at the ITIES. (C) 2010 Elsevier Ltd. All rights reserved.