| 1363417-22-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1363417-22-4
• 化学式: C₁₈H₂₁NO₃S
• 分子量: 331.436
• InChiKey: JTILEZRDNUTGBK-UHFFFAOYSA-N

物化性质

• 沸点：
  479.0±45.0 °C(predicted)
• 密度：
  1.24±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为产物：
  描述：

  2-噻吩甲醛 、 乙酰乙酸乙酯 、 5,5-二甲基-1,3-环己二酮 在 ammonium acetate 作用下， 反应 1.0h， 以92%的产率得到
  参考文献：
  名称：

  Cobalt Nanoparticles Promoted Highly Efficient One Pot Four-Component Synthesis of 1,4-Dihydropyridines under Solvent-Free Conditions

  摘要：

  A straightforward and general method has been developed for the synthesis of C(5)-unsubstitiuted 1,4-dihydropyridines by a reaction using dimedone, acetophenone, aromatic aldehydes, and ammonium acetate in the presence of a catalytic amount of Co nanoparticles as a heterogeneous and eco-friendly catalyst with high catalytic activity at room temperature under solvent-free conditions. This catalyst is easily separated by magnetic devices and can be reused without any apparent loss of activity for the reaction. In addition, it is very interesting that when using Co nanoparticles as a catalyst, spatially-hindered aldehydes such as 2-methoxy-, 2-fluoro-, and 2-chloro-aldehydes are suitable for this reaction.

  DOI：

  10.1016/s1872-2067(10)60295-1