dimethyl (1S,2R)-3-hydroxycyclohex-4-ene-1,2-dicarboxylate | 949013-84-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: dimethyl (1S,2R)-3-hydroxycyclohex-4-ene-1,2-dicarboxylate
• CAS: 949013-84-7
• 化学式: C₁₀H₁₄O₅
• 分子量: 214.218
• InChiKey: SCUSKFWALXEQFF-YPVSKDHRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(trimethylsiloxy)-1,3-butadiene 、 富马酸二甲酯 在 (1S,2S,6R)-2-diphenylphosphinyl-6-(2-phenoxy)cyclohexanol 、 barium isopropoxide 四丁基氟化铵 、 溶剂黄146 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 1.58h， 以34%的产率得到dimethyl (1S,2R)-3-hydroxycyclohex-4-ene-1,2-dicarboxylate
  参考文献：
  名称：

  EP1995250

  摘要：

  公开号：

文献信息

• Design and synthesis of immobilized Tamiflu analog on resin for affinity chromatography
  作者：Yasuaki Kimura、Kenzo Yamatsugu、Motomu Kanai、Noriko Echigo、Takashi Kuzuhara、Masakatsu Shibasaki

  DOI：10.1016/j.tetlet.2009.01.142

  日期：2009.7

  A resin linked with the Tamiflu core was synthesized by modifying our original synthetic route Of oseltamivir phosphate (Tamiflu). The prepared resin bound to the influenza virus enzyme neuraminidase, the main target of Tamiflu. The immobilized Tamiflu analog will be useful for isolating and identifying presumed endogenous vertebrate proteins that interact with Tamiflu, which might relate to the abnormal behavior exhibited by some influenza patients treated with Tamiflu. (C) 2009 Elsevier Ltd. All rights reserved.
• Ligand, Method for Producing the Same, and Catalyst Using the Ligand
  申请人：Shibasaki Masakatsu

  公开号：US20090023579A1

  公开（公告）日：2009-01-22

  Disclosed is a novel asymmetric ligand which can be synthesized by a short process at low cost and is capable of exhibiting higher catalytic activity and enantioselectivity than the conventional ligands derived from sugars. Also disclosed are a method for producing such an asymmetric ligand, and a catalyst using such an asymmetric ligand. Specifically disclosed is a ligand represented by the general formula I below or the like. (In the formula, R 1 and R 2 independently represent 0-5 substituents; X represents P, As or N; m represents an integer of 0-7; n represents an integer of 0-3; A 1 -A 4 independently represent hydrogen, fluorine, chlorine, bromine, benzoyl or acetyl, or alternatively A 2 and A 3 combine together to form a ring.)
• US7820862B2
  申请人：——

  公开号：US7820862B2

  公开（公告）日：2010-10-26