亚磷酸单环己酯 | 2310-48-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 亚磷酸单环己酯
• 英文名称: monocyclohexyl phosphite
• 英文别名: cyclohexyl phosphite；Phosphonsaeure-monocyclohexylester；Cyclohexyl hydrogen phosphonate；phosphonic acid monocyclohexyl ester；cyclohexylphosphonate
• CAS: 2310-48-7
• 化学式: C₆H₁₃O₃P
• 分子量: 164.141
• InChiKey: XZTMYDGMWDHMDR-UHFFFAOYSA-N

物化性质

• 沸点：
  271.0±23.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.72
• 重原子数：
  10.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.53
• 氢给体数：
  1.0
• 氢受体数：
  2.0

安全信息

• 海关编码：
  2915900090

反应信息

• 作为反应物：
  描述：

  亚磷酸单环己酯 、 环己醇 在 四磷十氧化物 作用下， 反应 3.33h， 以39.5%的产率得到dicyclohexyl phosphonate
  参考文献：
  名称：

  Method for the esterification of P-O components

  摘要：

  本发明涉及一种新的P-O组分酯化方法。更具体地说，本发明涉及一种新的P-O组分酯化方法，其含有至少一个P-O-H官能团，其中P-O-H官能团被转化为P-O-R官能团。根据本发明的方法可能特别适用于磷酸二酯的制造。

  公开号：

  EP2581378A1
• 作为产物：
  描述：

  在 水 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 生成 亚磷酸单环己酯
  参考文献：
  名称：

  New type phosphorous amides derived from protected monosaccharides

  摘要：

  Three synthetic routes to hydrogen phosphoramidites derived from protected hydrocarbons containing one free secondary hydroxy group are explored: phosphorylation with (diethylamido)phosphorous dichloride, acidolysis of tetraalkyldiamides derived from sugars, and phosphorylation with phosphorous tetra-alkyldiamides. The last route was found to be preferred. Some properties of the prepared dialkylamidoglycophosphites were studied: stability, phosphorylating activity, and behavior in oxidation reactions.

  DOI：

  10.1134/s1070363206040062

文献信息

• Method and compositions for identifying anti-HIV therapeutic compounds
  申请人：Arimilli N. Murty

  公开号：US20050239054A1

  公开（公告）日：2005-10-27

  Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.

  提供了一种识别含有羧酸酯或磷酸酯基团取代的抗HIV治疗化合物的方法。可以选择使用新型酶GS-7340酯水解酶对这类化合物库进行筛选。还提供了与GS-7340酯水解酶相关的组合物和方法。
• METHOD FOR PRODUCING ALKENYL PHOSPHORUS COMPOUND
  申请人：MARUZEN PETROCHEMICAL CO., LTD.

  公开号：US20190263847A1

  公开（公告）日：2019-08-29

  Provided is a method for producing an alkenyl phosphorus compound which can produce an alkenyl phosphorus compound efficiently even with a smaller amount of a catalyst used than that used conventionally, and further which can maintain catalytic activity to produce an alkenyl phosphorus compound in high yield even at a larger reaction scale, and which can also be applied to quantity synthesis at an industrial scale using a conventional batch reactor or continuous reactor. A method for producing an alkenyl phosphorus compound, comprising: a step of reacting a compound represented by the following formula (1): [In formula (1), R 1 represents OR 3 or R 3 , R 2 represents OR 4 or R 4 , and R 3 and R 4 represent, for example, each independently a substituted or unsubstituted alkyl group.] with a compound represented by the following formula (2): R 5 —C≡CH  (2) [In formula (2), R 5 represents, for example, a hydrogen atom, or a substituted or unsubstituted alkyl group.] to produce the phosphorus alkenyl compound presented by at least any of the following formulas (3a) or (3b): [In formulas (3a) and (3b), R 1 and R 2 have the same meaning as defined in formula (1), and R 5 has the same meaning as defined in formula (2).], In which the compound represented by formula (1) is reacted with the compound represented by formula (2) using a transition metal catalyst, and a phosphorus oxo acid compound having an intramolecular P—H bond.

  提供的是一种生产烯基磷化合物的方法，该方法即使使用的催化剂量比传统方法少，也能高效地生产烯基磷化合物，而且能够在更大的反应规模下保持催化活性，以高收率生产烯基磷化合物，并且还可以在传统的批量反应器或连续反应器中进行工业规模的量产合成。 生产烯基磷化合物的方法包括以下步骤： 将以下式（1）所表示的化合物与以下式（2）所表示的化合物反应： 式（1）中，R1代表OR3或R3，R2代表OR4或R4，R3和R4例如各自独立地代表取代或未取代的烷基基团。 式（2）中，R5例如代表氢原子，或代表取代或未取代的烷基基团。 从而产生至少以下任一式（3a）或（3b）所表示的磷烯烃化合物： 式（3a）和（3b）中，R1和R2的含义与式（1）中定义的相同，R5的含义与式（2）中定义的相同。 其中，使用过渡金属催化剂和具有分子内P-H键的磷氧酸化合物使式（1）所表示的化合物与式（2）所表示的化合物反应。
• Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds
  申请人：Arimilli N. Murty

  公开号：US20050209197A1

  公开（公告）日：2005-09-22

  Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

  本发明揭示了具有抗HIV蛋白酶活性的膦酸酯取代化合物，可用作治疗剂和其他工业用途。该组合物抑制HIV蛋白酶活性和/或在治疗艾滋病和其他抗病毒感染方面有用，以及在检测HIV蛋白酶的测定中有用。
• Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds
  申请人：Arimilli N. Murty

  公开号：US20070010489A1

  公开（公告）日：2007-01-11

  Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

  本发明揭示了具有HIV蛋白酶抑制剂性质的膦酸酯取代化合物，其具有作为治疗剂和其他工业用途的用途。该组合物抑制5型HIV蛋白酶活性和/或在治疗艾滋病和其他抗病毒感染方面具有治疗作用，以及在检测HIV蛋白酶方面的检测中有用。
• Method for producing alkenyl phosphorus compound
  申请人：MARUZEN PETROCHEMICAL CO., LTD.

  公开号：US10479809B2

  公开（公告）日：2019-11-19

  Provided is a method for producing an alkenyl phosphorus compound which can produce an alkenyl phosphorus compound efficiently even with a smaller amount of a catalyst used than that used conventionally, and further which can maintain catalytic activity to produce an alkenyl phosphorus compound in high yield even at a larger reaction scale, and which can also be applied to quantity synthesis at an industrial scale using a conventional batch reactor or continuous reactor. A method for producing an alkenyl phosphorus compound, comprising: a step of reacting a compound represented by the following formula (1): [In formula (1), R1 represents OR3 or R3, R2 represents OR4 or R4, and R3 and R4 represent, for example, each independently a substituted or unsubstituted alkyl group.] with a compound represented by the following formula (2): [In formula (2), R5 represents, for example, a hydrogen atom, or a substituted or unsubstituted alkyl group.] to produce the phosphorus alkenyl compound presented by at least any of the following formulas (3a) or (3b): [In formulas (3a) and (3b), R1 and R2 have the same meaning as defined in formula (1), and R5 has the same meaning as defined in formula (2).], In which the compound represented by formula (1) is reacted with the compound represented by formula (2) using a transition metal catalyst, and a phosphorus oxo acid compound having an intramolecular P—H bond.

  本发明提供了一种生产烯基磷化合物的方法，与传统方法相比，该方法即使使用较少量的催化剂也能高效生产烯基磷化合物，而且即使在较大的反应规模下也能保持催化活性以高产率生产烯基磷化合物，该方法还可用于使用传统的间歇反应器或连续反应器进行工业规模的定量合成。 一种生产烯基磷化合物的方法，包括 使下式（1）代表的化合物反应的步骤： 式（1）中，R1 代表 OR3 或 R3，R2 代表 OR4 或 R4，R3 和 R4 例如各自独立地代表取代或未取代的烷基。 与下式（2）所代表的化合物： 式（2）中，R5 代表氢原子或取代或未取代的烷基。 生成至少由以下任何式子（3a）或（3b）表示的磷烯基化合物： [在式 (3a) 和 (3b) 中，R1 和 R2 与式 (1) 所定义的含义相同，R5 与式 (2) 所定义的含义相同、］ 其中，使用过渡金属催化剂使式（1）代表的化合物与式（2）代表的化合物以及具有分子内 P-H 键的氧化磷化合物反应。