4-Phenyl-2-(N-methyl-acetylamino)-thiazol | 14269-51-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-Phenyl-2-(N-methyl-acetylamino)-thiazol
• 英文别名: N-methyl-N-(4-phenyl-1,3-thiazol-2-yl)acetamide
• CAS: 14269-51-3
• 化学式: C₁₂H₁₂N₂OS
• 分子量: 232.306
• InChiKey: ISSGVPWXORSXHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  61.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-methyl-4-phenyl-1,3-thiazol-2-amine 、 乙酸酐 在 sodium acetate 作用下， 生成 4-Phenyl-2-(N-methyl-acetylamino)-thiazol
  参考文献：
  名称：

  Selim,M. et al., Bulletin de la Societe Chimique de France, 1966, p. 3403 - 3407

  摘要：

  DOI：

文献信息

• SMALL MOLECULE ACTIVATORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS AND METHODS OF USE
  申请人：Verkman Alan S.

  公开号：US20140378510A1

  公开（公告）日：2014-12-25

  Provided herein are small molecule activators of calcium-activated chloride channels. These small molecules may be used for treatment of diseases and disorders that are treatable by activating calcium-activated chloride channels, such as cystic fibrosis, disorders related to salivary gland dysfunction (for example, Sjogren's syndrome and dysfunction following radiation injury), dry eye syndrome, and intestinal hypomotility.

  本文提供的是钙激活氯通道的小分子激活剂。这些小分子可以用于治疗可通过激活钙激活氯通道治疗的疾病和障碍，例如囊性纤维化、与唾液腺功能障碍相关的疾病（例如Sjogren综合症和放射性损伤后的功能障碍）、干眼症和肠道低动力性。
• ANTI-MIGRATION AND ANTI-INVASION THIAZOLE ANALOGS FOR TREATMENT OF CELLULAR PROLIFERATIVE DISEASE
  申请人：XAVIER UNIVERSITY OF LOUISIANA

  公开号：US20150274714A1

  公开（公告）日：2015-10-01

  Thiazole analog compounds and their pharmaceutically acceptable salts are disclosed, including pharmaceutical compositions comprising the thiazole analog compounds, either alone or in combination with at least one additional therapeutic agent, and/or with a pharmaceutically acceptable carrier. Methods of using the thiazole analog compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative diseases, such as cancer, are also disclosed.
• US9790218B2
  申请人：——

  公开号：US9790218B2

  公开（公告）日：2017-10-17