4-hexanoyl-1,3-dihydro-imidazol-2-one | 71647-94-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-hexanoyl-1,3-dihydro-imidazol-2-one
• 英文别名: 4-Hexanoyl-1,3-dihydro-imidazol-2-on；1,3-dihydro-4-(1-oxohexyl)-2H-imidazol-2-one；4-Hexanoyl-1,3-dihydroimidazol-2-one
• CAS: 71647-94-4
• 化学式: C₉H₁₄N₂O₂
• 分子量: 182.222
• InChiKey: HSAAFSHWABHWJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-hexanoyl-1,3-dihydro-imidazol-2-one 在 溶剂黄146 、 铂 作用下， 生成 4-hexyl-imidazolidin-2-one
  参考文献：
  名称：

  Specific Force Deficit in Skeletal Muscles of Old Rats Is Partially Explained by the Existence of Denervated Muscle Fibers

  摘要：

  We tested the hypothesis that denervated muscle fibers account for part of the specific force (sF(0)) deficit observed in muscles from old adult (OA) mammals, Whole muscle force (F-0) was quantified for extensor digitorum longus (EDL) muscles of OA and young adult (YA) rats. EDL muscle sF(0) was calculated by dividing F-0 by either total muscle fiber cross-sectional area (CSA) or by innervated fiber CSA. Innervated fiber CSA was estimated from EDL muscle cross sections labeled for neural cell adhesion molecules, whose presence is a marker for muscle fiber denervation. EDL muscles from OA rats contained significantly more denervated fibers than muscles from YA rats (5.6% vs 1.1% of total CSA), When compared with YA muscle, oil muscle demonstrated deficits of 34.1% for F-0, 28.3% for sF(0), and 24.9 % for sF(0) calculated by using innervated CSA as the denominator, Denervated muscle fibers accounted for 11.3% of the specific force difference between normal YA and OA skeletal muscle, Other mechanisms in addition to denervation account for the majority of the sF(0) deficit with aging.

  DOI：

  10.1093/gerona/56.5.b191
• 作为产物：
  描述：

  己酰氯 生成 4-hexanoyl-1,3-dihydro-imidazol-2-one
  参考文献：
  名称：

  Method for the treatment of cardiac failure with alkanoylimidazol-2-one

  摘要：

  以下一般结构的4-癸酰基咪唑酮在治疗心力衰竭中作为心力药物是有用的，其中Q和T分别是氧原子或二价硫原子；R是氢、较低烷基、较低烷基羰基或苯甲酰基；R.sub.1是氢或较低烷基；R.sub.2是较低脂肪烃基、苯基烷基或杂环烷基；以及其药用可接受的盐。

  公开号：

  US04367236A1

文献信息

• Novel substituted alkanoylimidazol-2-one derivatives
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0079049B1

  公开（公告）日：1987-04-01
• US4367236A
  申请人：——

  公开号：US4367236A

  公开（公告）日：1983-01-04
• US4447619A
  申请人：——

  公开号：US4447619A

  公开（公告）日：1984-05-08
• Specific Force Deficit in Skeletal Muscles of Old Rats Is Partially Explained by the Existence of Denervated Muscle Fibers
  作者：M. G. Urbanchek、E. B. Picken、L. K. Kalliainen、W. M. Kuzon

  DOI：10.1093/gerona/56.5.b191

  日期：2001.5.1

  We tested the hypothesis that denervated muscle fibers account for part of the specific force (sF(0)) deficit observed in muscles from old adult (OA) mammals, Whole muscle force (F-0) was quantified for extensor digitorum longus (EDL) muscles of OA and young adult (YA) rats. EDL muscle sF(0) was calculated by dividing F-0 by either total muscle fiber cross-sectional area (CSA) or by innervated fiber CSA. Innervated fiber CSA was estimated from EDL muscle cross sections labeled for neural cell adhesion molecules, whose presence is a marker for muscle fiber denervation. EDL muscles from OA rats contained significantly more denervated fibers than muscles from YA rats (5.6% vs 1.1% of total CSA), When compared with YA muscle, oil muscle demonstrated deficits of 34.1% for F-0, 28.3% for sF(0), and 24.9 % for sF(0) calculated by using innervated CSA as the denominator, Denervated muscle fibers accounted for 11.3% of the specific force difference between normal YA and OA skeletal muscle, Other mechanisms in addition to denervation account for the majority of the sF(0) deficit with aging.
• Method for the treatment of cardiac failure with alkanoylimidazol-2-one
  申请人：Merrell Dow Pharmaceuticals Inc.

  公开号：US04367236A1

  公开（公告）日：1983-01-04

  4-Alkanoylimidazol-2-ones of the following general structure which are useful as cardiotonics in the treatment of cardiac failure ##STR1## wherein Q and T are each an oxygen atom or a divalent sulfur atom; R is hydrogen, lower alkyl, lower alkylcarbonyl or benzoyl; R.sub.1 is hydrogen or lower alkyl; R.sub.2 is a lower aliphatic hydrocarbon radical, phenyl alkylene or heterocyclo alkylene; and the pharmaceutically acceptable salts thereof.

  以下一般结构的4-癸酰基咪唑酮在治疗心力衰竭中作为心力药物是有用的，其中Q和T分别是氧原子或二价硫原子；R是氢、较低烷基、较低烷基羰基或苯甲酰基；R.sub.1是氢或较低烷基；R.sub.2是较低脂肪烃基、苯基烷基或杂环烷基；以及其药用可接受的盐。