2-Hydroxy-4-(3-methyl-1-oxobutyl)benzoic acid methyl ester | 1082071-96-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Hydroxy-4-(3-methyl-1-oxobutyl)benzoic acid methyl ester
• 英文别名: methyl 2-hydroxy-4-(3-methylbutanoyl)benzoate
• CAS: 1082071-96-2
• 化学式: C₁₃H₁₆O₄
• 分子量: 236.268
• InChiKey: XDPRKMZIDKSBEW-UHFFFAOYSA-N

物化性质

• 沸点：
  370.1±32.0 °C(Predicted)
• 密度：
  1.140±0.06 g/cm3(Predicted)

反应信息

• 作为产物：
  描述：

  在 重铬酸吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 2-Hydroxy-4-(3-methyl-1-oxobutyl)benzoic acid methyl ester
  参考文献：
  名称：

  Optimization of small molecule agonists of the thrombopoietin (Tpo) receptor derived from a benzo[a]carbazole hit scaffold

  摘要：

  The lead optimization of a novel series of benzo[a] carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor is reported. The chemical instability of the dihydro-benzo[a] carbazole lead 2 was successfully addressed in the design and evaluation of compounds which also demonstrated improved potency compared to 2. Members of the scaffold have been identified which are full agonists that demonstrate cellular functional potency < 50 nM. Analog 21 demonstrates equivalent efficacy in the human megakaryocyte differentiation (CFU-mega) assay compared to Eltrombopag(TM). (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.077