1-amino-cyclopentylphosphinic acid | 65576-90-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-amino-cyclopentylphosphinic acid
• 英文别名: 1-aminocyclopentylphosphinic acid
• CAS: 65576-90-1
• 化学式: C₅H₁₂NO₂P
• 分子量: 149.13
• InChiKey: CACICIRSQKWQQF-UHFFFAOYSA-N

物化性质

• 沸点：
  290.1±42.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.68
• 重原子数：
  9.0
• 可旋转键数：
  1.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  63.32
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  环戊酮肟 在 亚膦酸 作用下， 以 异丙醇 为溶剂， 反应 24.5h， 以32%的产率得到1-amino-cyclopentylphosphinic acid
  参考文献：
  名称：

  (α-取代的 α-氨基次膦酸和 α-氨基膦酸的合成

  摘要：

  酮肟与次磷酸的反应产生了以前未知的 α-取代-α-氨基次膦酸，它们被氧化成相应的 α-取代-α-氨基膦酸。

  DOI：

  10.1007/bf01431122

文献信息

• Phosphonic acid derivative having inhibitory activity against carboxypeptidase B
  申请人：Meiji Seika Kaisha Ltd.

  公开号：US20030119787A1

  公开（公告）日：2003-06-26

  A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: 1 wherein R 1 represents hydrogen atom, an alkyl group, a substituted alkyl group and the like; R 2 and R 3 represent hydrogen atom, an alkyl group, a substituted alkyl group, an alkoxyl group and the like; X represents —CH 2 —, —O—, or —NH—; A represents the following group (II): 2 [in which R 7 and R 8 represent hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group and the like; R 9 and R 10 represents hydrogen atom, a halogen atom, hydroxyl group, phenyl group, an alkyl group and the like] and the like; and E represents hydrogen atom and the like, which has inhibitory activity against carboxypeptidase B and is useful for therapeutic and/or preventive treatment of a thrombotic disease.

  以下是通用式（I）及其药学上可接受的盐所代表的化合物：其中R1代表氢原子、烷基、取代烷基等；R2和R3代表氢原子、烷基、取代烷基、烷氧基等；X代表—CH2—、—O—或—NH—；A代表以下基团（II）：其中R7和R8代表氢原子、烷基、酰基、烷氧羰基等；R9和R10代表氢原子、卤素原子、羟基、苯基、烷基等；E代表氢原子等，具有对羧肽酶B的抑制活性，可用于治疗和/或预防血栓性疾病。
• Phosphonic acid derivatives having carboxypeptidase b inhibitory activity
  申请人：Meiji Seika Kaisha Ltd.

  公开号：US06576627B1

  公开（公告）日：2003-06-10

  A compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof: wherein R1 represents hydrogen atom, an alkyl group, a substituted alkyl group and the like; R2 and R3 represent hydrogen atom, an alkyl group, a substituted alkyl group, an alkoxyl group and the like; X represents —CH2—, —O—, or —NH—; A represents the following group (II): [in which R7 and R8 represent hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group and the like; R9 and R10 represents hydrogen atom, a halogen atom, hydroxyl group, phenyl group, an alkyl group and the like] and the like; and E represents hydrogen atom and the like, which has inhibitory activity against carboxypeptidase B and is useful for therapeutic and/or preventive treatment of a thrombotic disease.

  以下是通式（I）及其药学上可接受的盐所代表的化合物： 其中，R1代表氢原子，烷基，取代烷基等；R2和R3代表氢原子，烷基，取代烷基，烷氧基等；X代表—CH2—、—O—或—NH—；A代表以下基团（II）： 【其中，R7和R8代表氢原子，烷基，酰基，烷氧羰基等；R9和R10代表氢原子，卤素原子，羟基，苯基，烷基等等；E代表氢原子等，具有对羧肽酶B的抑制活性，可用于治疗和/或预防血栓性疾病。】
• DE2722162
  申请人：——

  公开号：——

  公开（公告）日：——