(E)-3-(4-(dimethoxymethyl)phenyl) acrylic acid | 63756-91-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (E)-3-(4-(dimethoxymethyl)phenyl) acrylic acid
• 英文别名: 3-[4-(Dimethoxymethyl)phenyl]prop-2-enoic acid
• CAS: 63756-91-2
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: KUBIGZREOGXEDN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9h-purin-8-YI)phenyl derivatives, their preparation and their use in the treatment of inflammatory conditions and immune disorders
  申请人：——

  公开号：US20030181471A1

  公开（公告）日：2003-09-25

  1. A compound of formula (I) 1 or a solvate thereof wherein: X is —O— or —NH—; Q is (—CH 2 —) p , (—CH═CH—) p , (—C≡C—) p where p is an integer of from 0 to 4; R 1 is hydrogen or methyl; R 2 and R 3 independently represent O or S n is an integer of 1 to 50; and R is hydrogen or methyl.

  化合物式（I）的复合物或其溶剂化物，其中：X为—O—或—NH—;Q为（—CH2—）p，（—CH═CH—）p，（—C≡C—）p，其中p为0至4的整数；R1为氢或甲基；R2和R3独立地表示O或Sn为1至50的整数；而R为氢或甲基。
• Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
  申请人：Lehmann-Lintz Thorsten

  公开号：US20050267093A1

  公开（公告）日：2005-12-01

  Compounds of formula (I) wherein A, B, b, W, X, Y, Z, R 1 , R 2 , and R 3 have the meanings given in claim 1, pharmaceutical compositions these compounds, and methods of preventing or treating metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia, and diabetes using these compounds.

  化合物的公式（I），其中A，B，b，W，X，Y，Z，R1，R2和R3具有权利要求1所给出的含义，制备这些化合物的药物组合物，以及使用这些化合物预防或治疗代谢紊乱和/或进食障碍，特别是肥胖症，暴食症，厌食症，暴饮暴食和糖尿病的方法。
• Compounds as histone deacetylase 6 inhibitors and pharmaceutical compositions comprising the same
  申请人：CHONG KUN DANG PHARMACEUTICAL CORP.

  公开号：US10287255B2

  公开（公告）日：2019-05-14

  A compound of formula (I), having histone deacetylase 6 (HDAC6) inhibitory activity, wherein X, Q, N, R1, R2, L, and n are as described, isomers thereof, or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions comprising the same, a method of treating disease using the composition, and methods for preparing the novel compounds. The novel compounds according to the present invention have histone deacetylase 6 (HDAC6) inhibitory activity, and are effective for the prevention or treatment of HDAC6-associated diseases, including cancer, inflammatory diseases, autoimmune diseases, neurological diseases and neurodegenerative disorders.

  具有组蛋白去乙酰化酶 6 (HDAC6) 抑制活性的式 (I) 化合物、 其中X、Q、N、R1、R2、L和n如所述，其异构体或其药学上可接受的盐、其用于制备治疗药物的用途、包含其的药物组合物、使用该组合物治疗疾病的方法以及制备该新型化合物的方法。根据本发明的新型化合物具有组蛋白去乙酰化酶6（HDAC6）抑制活性，可有效预防或治疗HDAC6相关疾病，包括癌症、炎症性疾病、自身免疫性疾病、神经系统疾病和神经退行性疾病。
• PHENYL XANTHINE DERIVATIVES
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0775141A1

  公开（公告）日：1997-05-28
• SUBSTITUTED (1,3-BIS(CYCLOHEXYLMETHYL)-1,2,3,6-TETRAHYDRO-2,6-DIOXO-9H-PURIN-8-YL)PHENYL DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF INFLAMMATORY CONDITIONS AND IMMUNE DISORDERS
  申请人：GLAXO GROUP LIMITED

  公开号：EP0970081A1

  公开（公告）日：2000-01-12