| 1024001-69-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• CAS: 1024001-69-1
• 化学式: C₂₆H₂₂Cl₃N₃O₃
• 分子量: 530.838
• InChiKey: BKFCJZUQPVIHLT-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  C₃₁H₃₀Cl₃N₃O₅ 在 盐酸 作用下， 以 乙酸乙酯 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors

  摘要：

  Synthesis and biological activities of some quinolinone and dihydroquinolinone p38 MAP kinase inhibitors are reported. Modi. cations to the dihydroquinolinone pharmacophore revealed that dihydroquinolinone may be replaced with a quinolinone pharmacophore and lead to enhanced p38 inhibitory activity. From a study of C-7 substitutions by amino acid side chains, a very potent series of compounds in the p38 enzyme assays was identified. Translation of the in vitro activity into reasonable whole blood activity can be improved in this series of compounds by judicious modi. cation of the physical properties at appropriate regions of the lead. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.10.097