(3R,6S)-3-[(R)-1-(1-Methylindol-3-yl)ethyl]-6-(2-quinolylmethyl)piperazine-2,5-dione | 112319-55-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (3R,6S)-3-[(R)-1-(1-Methylindol-3-yl)ethyl]-6-(2-quinolylmethyl)piperazine-2,5-dione
• 英文别名: (3R,6S)-3-[(1R)-1-(1-methylindol-3-yl)ethyl]-6-(quinolin-2-ylmethyl)piperazine-2,5-dione
• CAS: 112319-55-8
• 化学式: C₂₅H₂₄N₄O₂
• 分子量: 412.491
• InChiKey: GZKHNRBULDXPQL-LDLFBNOTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  31
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Piperazine compound as PAF-antagonist
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0243122A2

  公开（公告）日：1987-10-28

  A piperazine compound of the formula: wherein R' and R" are each hydrogen or lower alkyl, R1 is 1-(1-methylindol-3-yl)ethyl, 1-(1-ethylindol-3-yl)ethyl, 1-(1-propylindol-3-yl)ethyl, 1-(1,2-dimethylindol-3-yl)ethyl, 1-(1-methyl-2-phenylindol-3-yl)ethyl, 1-(1,5-dimethylindol-3-yl)ethyl, 1-(5-methyl-1-propylindol-3-yl)ethyl, 1-(2,5-dimethyl-1-propylindol-3-yl)ethyl, 1-(1,2,5-trimethylindol-3-yl)ethyl 1-(1-butyl-2-methylindol-3-yllethyl, 1-(1-isobutylindol-3-yl)ethyl, 1-(1-methylindol-3-yl)propyl, 1-(1-ethyl-6-methylindol-3-yl)ethyl or 1-(1-ethyl-5-methylindol-3-yl)ethyl, R2 is 2-pyridylmethyl; or R1 is 1-methylindol-3-ylmethyl and R2 is 3-(or 4-)pyridylmethyl; or R1 is 1-naphthylmethyl and R2 is butyl or R1 is heterocyclic(lower)alkyl which may have one or more lower alkyl(s) on the heterocyclic ring and R2 is thiazolyl(lower)alkyl, quinolyl(tower)alkyl, tetahydropyridyl(lower)alkyl which may have lower alkyl on the tetrahydropyridine ring, or a group of the formula: wherein A is lower alkylene, R3 is lower alkyl and X is acid residue; or R1 is indolyl(lower)alkyl having lower alkyl and lower alkoxy on the indole ring, indolyl(lower)alkyl having one or more lower alkyl(s) and halogen on the indole ring, indolyl(lower)alkyl having lower alkyl and ar(lower)alkoxy on the indole ring or indolylar-(lower)alkyl having lower alkyl on the indole ring and R2 is heterocyclic(lower)alkyl, and pharmaceutically acceptable salt thereof, which are highly potent antagonists of PAF, processes for the preparation thereof and a pharmaceutical composition comprising the same.

  一种哌嗪化合物，其式如下 其中 R' 和 R" 均为氢或低级烷基、 R1 是 1-(1-甲基吲哚-3-基)乙基、 1-(1-乙基吲哚-3-基)乙基 1-(1-丙基吲哚-3-基)乙基 1-(1,2-二甲基吲哚-3-基)乙基、 1-(1-甲基-2-苯基吲哚-3-基)乙基 1-(1,5-二甲基吲哚-3-基)乙基 1-(5-甲基-1-丙基吲哚-3-基)乙基 1-(2,5-二甲基-1-丙基吲哚-3-基)乙基、 1-(1,2,5-三甲基吲哚-3-基)乙基 1-(1-丁基-2-甲基吲哚-3-基乙基) 1-(1-异丁基吲哚-3-基)乙基、 1-(1-甲基吲哚-3-基)丙基、 1-(1-乙基-6-甲基吲哚-3-基)乙基或 1-(1-乙基-5-甲基吲哚-3-基)乙基、 R2 是 2-吡啶甲基；或 R1 是 1-甲基吲哚-3-基甲基和 R2 是 3-（或 4-）吡啶基甲基；或 R1 是 1-萘甲基，R2 是丁基或萘甲基。 R2是丁基或 R1 是杂环（低级）烷基，杂环上可能有一个或多个低级烷基，且 R2 是噻唑基（低级）烷基、 喹啉基（塔）烷基、 四氢吡啶（低级）烷基（四氢吡啶环上可能有低级烷基）或式中的一个基团： 其中 A 为低级亚烷基、 R3 是低级烷基 X 是酸残基；或 R1 是在吲哚环上具有低级烷基和低级烷氧基的吲哚基(低级)烷基、在吲哚环上具有一个或多个低级烷基和卤素的吲哚基(低级)烷基、在吲哚环上具有低级烷基和ar(低级)烷氧基的吲哚基(低级)烷基或在吲哚环上具有低级烷基的吲哚基ar-(低级)烷基，以及 R2 是杂环（低级）烷基及其药学上可接受的盐，它们是 PAF 的强效拮抗剂，其制备方法和包含它们的药物组合物。
• US4806538A
  申请人：——

  公开号：US4806538A

  公开（公告）日：1989-02-21
• US4940709A
  申请人：——

  公开号：US4940709A

  公开（公告）日：1990-07-10