4-methyl-5-hydroxyquinolin-2-one | 131195-67-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-methyl-5-hydroxyquinolin-2-one
• 英文别名: 5-hydroxy-4-methyl-2(1H)-quinolinone；5-Hydroxy-4-methylquinolin-2(1H)-one；5-hydroxy-4-methyl-1H-quinolin-2-one
• CAS: 131195-67-0
• 化学式: C₁₀H₉NO₂
• 分子量: 175.187
• InChiKey: VLYITQSRMVYHLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙酰乙酸乙酯 、 3-氨基苯酚 生成 4-methyl-5-hydroxyquinolin-2-one
  参考文献：
  名称：

  CHILIN, A.;RODIGHIERO, P.;PASTORINI, G.;GUIOTTO, A., J. ORG. CHEM., 56,(1991) N, C. 980-983

  摘要：

  DOI：

文献信息

• New synthesis of pyrrolo [3,2,1-ij] quinolin-4-one derivatives
  作者：A. Chilin、P. Rodighiero、G. Pastorini、Adriano Guiotto

  DOI：10.1021/jo00003a016

  日期：1991.2

  A new convenient synthesis of pyrrolo[3,2,1-ij]quinolin-4-one derivatives is described. In this method, methyl-7-hydroxquinoline-2-ones are the starting materials onto which the third pyrrolo ring is condensed directly, yielding dehydrogenated methyl-9-hydroxypyrrolo[3,2,1-ij]quinolin-4-ones.
• CHILIN, A.;RODIGHIERO, P.;PASTORINI, G.;GUIOTTO, A., J. ORG. CHEM., 56,(1991) N, C. 980-983
  作者：CHILIN, A.、RODIGHIERO, P.、PASTORINI, G.、GUIOTTO, A.

  DOI：——

  日期：——
• [EN] BICYCLIC COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS BICYCLIQUES ET LEURS MÉTHODES D'UTILISATION
  申请人：SCHERING CORP

  公开号：WO2011060036A1

  公开（公告）日：2011-05-19

  The present invention relates to certain novel bicyclic compounds, compositions comprising such bicyclic compounds and methods for using the Bicyclic compounds for treating or preventing a metabolic disorder, dyslipidemia, a cardiovascular disease, a neurological disorder, a hematological disease, cancer, inflammation, a respiratory disease, a gastroenterological disease, diabetes, a diabetic complicaton, obesity, an obesity-related disorder or non-alcoholic fatty liver disease. An illustrative bicyclic compound of the invention is shown below: