1-chloro-6H-indolo[2,3-b]quinoline | 1369774-03-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-chloro-6H-indolo[2,3-b]quinoline
• CAS: 1369774-03-7
• 化学式: C₁₅H₉ClN₂
• 分子量: 252.703
• InChiKey: UWTUYPAAIXMMLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3-吲哚甲醛 、 3-氯苯胺 在 碘 作用下， 以 二苯醚 为溶剂， 反应 12.0h， 以32%的产率得到1-chloro-6H-indolo[2,3-b]quinoline
  参考文献：
  名称：

  Iodine catalyzed one-pot synthesis of chloro-substituted linear and angular indoloquinolines and in vitro antiproliferative activity study of different indoloquinolines

  摘要：

  This article describes a facile one-pot synthesis of different chloro-substituted linear and angular indoloquinolines using iodine as a catalyst and in vitro antiproliferative activity of these chloro-substituted indoloquinolines (3e and 3f) and some indolo[2,3-b]quinolines (3a-d) against human hepatocellular carcinoma HepG2 and human breast carcinoma MCF-7 cells. Anti-proliferative assay against human hepatocellular carcinoma HepG2 and human breast carcinoma MCF-7 cells indicated methyl-substituted 6H-indolo[2,3-b]quinoline 3c to be the most active and the parent 6H-indolo[2,3-b]quinoline 3a to be the least active, while the other compounds including the different chloro derivatives exhibited only intermediate activity.

  DOI：

  10.1007/s00044-012-0015-0

文献信息

• Materials for organic electroluminescent devices
  申请人：Merck Patent GmbH

  公开号：US10923665B2

  公开（公告）日：2021-02-16

  The present invention relates to compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.

  本发明涉及适用于电子设备的化合物，以及包括这些化合物的电子设备，特别是有机电致发光器件。
• MATERIALIEN FÜR ORGANISCHE ELEKTROLUMINESZENZVORRICHTUNGEN
  申请人：Merck Patent GmbH

  公开号：EP3583104B1

  公开（公告）日：2021-06-09
• MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES
  申请人：Merck Patent GmbH

  公开号：US20200044162A1

  公开（公告）日：2020-02-06

  The present invention relates to compounds suitable for use in electronic devices, and to electronic devices, especially organic electroluminescent devices, comprising these compounds.