1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-ethylurea | 1575698-47-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-ethylurea
• 英文别名: 1-(2,5-Dimethylpyrazol-3-yl)-3-ethylurea
• CAS: 1575698-47-3
• 化学式: C₈H₁₄N₄O
• 分子量: 182.225
• InChiKey: OTCNGDLDZGNENU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.87
• 重原子数：
  13.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  58.95
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-ethylurea 、 靛红 在 三甲基氯硅烷 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 10.0h， 以76%的产率得到5'-ethyl-1',3'-dimethyl-5',7'-dihydrospiro[indoline-3,4'-pyrazolo[3,4-d]pyrimidine]-2,6'(1'H)-dione
  参考文献：
  名称：

  Synthesis of pyrazolo[3,4-d]-4,5-dihydropyrimidin-6-ones

  摘要：

  A small library of hitherto unprepared pyrazolo[3,4-d]-4,5-dihydropyrimidin-6-ones was synthesized on a preparative scale. The synthesis starts with a substituted 5-aminopyrazole that reacts with an isocyanate to give the corresponding urea. The latter undergoes a chlorotrimethylsilane-promoted [5+1] cyclocondensation with an aldehyde yielding the title pyrazolo[3,4-d]-4,5-dihydropyrimidin-6-one. Both synthetic steps are high-yielding (74-94%). The intermediates and the target compounds were isolated by simple crystallization. Ketones with the exception of isatin do not react with the open-chain urea intermediates. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.01.131
• 作为产物：
  描述：

  5-氨基-1,3-二甲基吡唑 、 异氰酸乙酯 以 乙腈 为溶剂， 以72%的产率得到1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-ethylurea
  参考文献：
  名称：

  Synthesis of pyrazolo[3,4-d]-4,5-dihydropyrimidin-6-ones

  摘要：

  A small library of hitherto unprepared pyrazolo[3,4-d]-4,5-dihydropyrimidin-6-ones was synthesized on a preparative scale. The synthesis starts with a substituted 5-aminopyrazole that reacts with an isocyanate to give the corresponding urea. The latter undergoes a chlorotrimethylsilane-promoted [5+1] cyclocondensation with an aldehyde yielding the title pyrazolo[3,4-d]-4,5-dihydropyrimidin-6-one. Both synthetic steps are high-yielding (74-94%). The intermediates and the target compounds were isolated by simple crystallization. Ketones with the exception of isatin do not react with the open-chain urea intermediates. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.01.131