6-fluoro-4-(4-fluoro-butylamino)-8-methoxy-quinoline-3-carboxylic acid ethyl ester | 1174227-21-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-fluoro-4-(4-fluoro-butylamino)-8-methoxy-quinoline-3-carboxylic acid ethyl ester
• 英文别名: ethyl 6-fluoro-4-(4-fluorobutylamino)-8-methoxyquinoline-3-carboxylate
• CAS: 1174227-21-4
• 化学式: C₁₇H₂₀F₂N₂O₃
• 分子量: 338.354
• InChiKey: NNTYQTOGYRIYHJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  60.4
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  Ethyl 4-chloro-6-fluoro-8-methoxyquinoline-3-carboxylate 、 4-fluoro-butylamine 以to afford 6-fluoro-4-(4-fluoro-butylamino)-8-methoxy-quinoline-3-carboxylic acid ethyl ester (175 mg)的产率得到6-fluoro-4-(4-fluoro-butylamino)-8-methoxy-quinoline-3-carboxylic acid ethyl ester
  参考文献：
  名称：

  Tricyclic Compounds as Modulators of TNF-alpha Synthesis and as PDE4 Inhibitors

  摘要：

  本发明涉及化学式（I）所定义的化合物，制药组合物以及在治疗由TNF-α或PDE4介导的疾病或疾病中使用的方法，包括但不限于类风湿性关节炎。

  公开号：

  US20110160234A1

文献信息

• [EN] TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-a SYNTHESIS AND AS PDE4 INHIBITORS<br/>[FR] COMPOSÉS TRICYCLIQUES UTILISÉS EN TANT QU'INHIBITEURS DE LA SYNTHÈSE DE TNF-? ET EN TANT QU'INHIBITEURS DE PDE4
  申请人：HIGH POINT PHARMACEUTICALS LLC

  公开号：WO2009094528A1

  公开（公告）日：2009-07-30

  The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-alpha or by PDE4, including but not limited to rheumatoid arthritis.

  本发明涉及化合物的化学式（I），如本文所定义，药物组合物以及在治疗由TNF-alpha或PDE4介导的疾病或疾病中的使用方法，包括但不限于类风湿关节炎。
• Tricyclic Compounds As Modulators of TNF-alpha Synthesis
  申请人：Mjalli Adnan M. M.

  公开号：US20100190808A1

  公开（公告）日：2010-07-29

  The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-alpha or by PDE4, including but not limited to rheumatoid arthritis.

  本发明涉及公式(I)所定义的化合物、药物组合物以及在治疗由TNF-alpha或PDE4介导的疾病或疾病中使用的方法，包括但不限于类风湿关节炎。
• Tricyclic compounds as modulators of TNF-α synthesis
  申请人：High Point Pharmaceuticals, LLC

  公开号：US07964608B2

  公开（公告）日：2011-06-21

  The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-alpha or by PDE4, including but not limited to rheumatoid arthritis.

  本发明涉及式（I）所定义的化合物、制药组合物以及在治疗由TNF-alpha或PDE4介导的疾病或疾病中使用的方法，包括但不限于类风湿性关节炎。
• Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors
  申请人：High Point Pharmaceuticals, LLC

  公开号：US08329715B2

  公开（公告）日：2012-12-11

  The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.

  本发明涉及化学式（I）所定义的化合物、制药组合物以及在治疗由TNF-α或PDE4介导的疾病或疾病中的使用方法，包括但不限于类风湿性关节炎。
• TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-ALPHA SYNTHESIS AND AS PDE4 INHIBITORS
  申请人：vTv Therapeutics LLC

  公开号：US20150374700A1

  公开（公告）日：2015-12-31

  The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to rheumatoid arthritis.

  本发明涉及公式（I）所定义的化合物、制药组合物及其在治疗由TNF-α或PDE4介导的疾病或症状方面的使用方法，包括但不限于类风湿性关节炎。