1-(3-Bromophenyl)-6-(dimethylamino)-1-(2-methoxyquinolin-3-yl)-2-naphthalen-2-ylhexan-2-ol | 1032357-96-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(3-Bromophenyl)-6-(dimethylamino)-1-(2-methoxyquinolin-3-yl)-2-naphthalen-2-ylhexan-2-ol
• CAS: 1032357-96-2
• 化学式: C₃₄H₃₅BrN₂O₂
• 分子量: 583.568
• InChiKey: YNLAYKSKIAIWLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  45.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• ANTIBACTERIAL QUINOLINE DERIVATIVES
  申请人：Guillemont Jérôme Emile Georges

  公开号：US20100029679A1

  公开（公告）日：2010-02-04

  The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): including any stereochemically isomeric form thereof, a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof. The claimed compounds are useful for the treatment of a bacterial infection. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of a bacterial infection and a process for preparing the claimed compounds.
• QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS
  申请人：Andries Koenraad Jozef Lodewijk Marcel

  公开号：US20100048585A1

  公开（公告）日：2010-02-25

  Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R 1 is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R 2 is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula; R 3 is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 1, 2 or 3; R 4 and R 5 are hydrogen, alkyl or benzyl; or R 4 and R 5 together and including the N to which they are attached may form a ring; R 6 is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkythioalkyl, Ar-alkyl or di(Ar)alkyl; or two vicinal R 6 radicals may be taken together to form a bivalent radical of formula —CH═CH—CH═CH—; r is 1, 2, 3, 4 or 5; R 7 is hydrogen, alkyl, Ar or Het; R 8 is hydrogen or alkyl; R 9 is oxo; or R 8 and R 9 together form the radical —CH═CH—N═.
• US8293732B2
  申请人：——

  公开号：US8293732B2

  公开（公告）日：2012-10-23
• US8841321B2
  申请人：——

  公开号：US8841321B2

  公开（公告）日：2014-09-23
• [EN] QUINOLINE DERIVATIVES AS ANTIBACTERIAL AGENTS<br/>[FR] DÉRIVÉS DE QUINOLINE EN TANT QU'AGENTS ANTIBACTÉRIENS
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2007000435A1

  公开（公告）日：2007-01-04

  [EN] Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of formula (Ia) or (Ib) a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof, a tautomeric form thereof or a N-oxide form thereof, wherein R¹ is hydrogen, halo, haloalkyl, cyano, hydroxy, Ar, Het, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl; p is 1, 2, 3 or 4; R² is hydrogen, hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono or di(alkyl)amino or a radical of formula ; R³ is alkyl, Ar, Ar-alkyl, Het or Het-alkyl; q is 1, 2 or 3; R⁴ and R⁵ are hydrogen, alkyl or benzyl; or R⁴ and R⁵ together and including the N to which they are attached may form a ring; R⁶ is hydrogen, halo, haloalkyl, hydroxy, Ar, alkyl, alkyloxy, alkylthio, alkyloxyalkyl, alkylthioalkyl, Ar-alkyl or di(Ar)alkyl ; or two vicinal R⁶ radicals may be taken together to form a bivalent radical of formula - CH=CH-CH=CH-; r is 1, 2, 3, 4 or 5; R⁷ is hydrogen, alkyl, Ar or Het; R⁸ is hydrogen or alkyl; R⁹ is oxo ; or R⁸ and R⁹ together form the radical -CH=CH-N=.
  [FR] La présente invention décrit l'emploi d'un composé dans la fabrication d'un médicament pour le traitement d'une infection bactérienne, à la condition que ladite infection bactérienne soit différente d'une infection mycobactérienne, ledit composé étant un composé de formule (Ia) ou (Ib) un sel d'addition acide ou basique de qualité pharmaceutique dudit composé, une forme isomère stéréochimique dudit composé, une forme tautomère ou un N-oxyde dudit composé, où R¹ représente un atome d'hydrogène ou d'halogène ou un groupement halogénoalkyle, cyano, hydroxy, Ar, Het, alkyle, alkoxy, alkylthio, alkyloxyalkyle, alkylthioalkyle, Ar-alkyle ou di(Ar)alkyle ; p est égal à 1, 2, 3 ou 4 ; R² représente un atome d'hydrogène ou un groupement hydroxy, mercapto, alkyloxy, alkyloxyalkyloxy, alkylthio, mono- ou di(alkyl)amino ou un radical de formule ; R³ représente un groupement alkyle, Ar, Ar-alkyle, Het ou Het-alkyle ; q est égal à 1, 2 ou 3 ; R⁴ et R⁵ représentent des atomes d'hydrogène ou des groupements alkyle ou benzyle ; ou R⁴ et R⁵ représentent un cycle ensemble et avec le N auquel ils sont liés ; R⁶ représente un atome d'hydrogène ou d'halogène ou un groupement halogénoalkyle, hydroxy, Ar, alkyle, alkyloxy, alkylthio, alkyloxyalkyle, alkylthioalkyle, Ar-alkyle ou di(Ar)alkyle ; ou deux radicaux R⁶ vicinaux peuvent être joints pour former un radical divalent de formule -CH=CH-CH=CH- ; r est égal à 1, 2, 3, 4 ou 5 ; R⁷ représente un atome d'hydrogène ou un groupement alkyle, Ar ou Het ; R⁸ représente un atome d'hydrogène ou un groupement alkyle ; R⁹ représente un groupement oxo ; ou R⁸ et R⁹ forment ensemble le radical -CH=CH-N=.