(+)-(1R,5R)-α-pinene | 514-14-7

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: (+)-(1R,5R)-α-pinene
• 英文别名: (+)-ζ-fenchene；(+)-ζ-Fenchen；(1R,4S)-2,7,7-trimethylbicyclo[2.2.1]hept-2-ene
• CAS: 514-14-7
• 化学式: C₁₀H₁₆
• 分子量: 136.237
• InChiKey: QWEFTWKQGYFNTF-DTWKUNHWSA-N

物化性质

• 沸点：
  146.2-146.8 °C(Press: 752 Torr)
• 密度：
  0.8626 g/cm3
• 溶解度：
  Insoluble in water, soluble in alcohol and perfume oils

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  氯仿 、 (+)-(1R,5R)-α-pinene 、 溴 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Long-term therapy of chronic non-malignant pain with potent opioids in an active police officer

  摘要：

  Purpose: To report the successful long-term use of methadone and tramadol in treating low back pain in a marine police officer.Principal findings: The patient sustained a work-related injury having fallen down stairs while on duty in 1990. After multiple operations for a prolapsed L5/S1 intervertebral disk, he was first seen at our pain clinic in 1994. Numerous systemic medications, invasive procedures, physiotherapy and psychotherapy were used to treat his pain, but without sustained effect.Methadone was started in late 1995 and tramadol in 2000. The current maintenance doses are methadone 20 mg and tramadol 200 mg, both twice daily. Apart from some initial disruption, the patient was soon able to return to full time work. Regular performance reports from his supervisors have always been excellent.Conclusion: The use of methadone in this police officer with chronic low back pain has been very successful despite the demanding nature of his job. The controversy surrounding, and further suggestions regarding long-term use of opioid therapy for nonmalignant pain are discussed.

  DOI：

  10.1007/bf03017384
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium isopropylate 作用下， 生成 (+)-(1R,5R)-α-pinene
  参考文献：
  名称：

  Hueckel; Rohrer, Chemische Berichte, 1960, vol. 93, p. 1053,1059

  摘要：

  DOI：

文献信息

• Pulkkinen, Annales Academiae Scientiarum Fennicae, Series A2: Chemica, 1956, # 74, p. 7,57, 82
  作者：Pulkkinen

  DOI：——

  日期：——
• Hueckel; Meinhardt, Chemische Berichte, 1957, vol. 90, p. 2025,2034
  作者：Hueckel、Meinhardt

  DOI：——

  日期：——
• Hueckel; Rohrer, Chemische Berichte, 1960, vol. 93, p. 1053,1059
  作者：Hueckel、Rohrer

  DOI：——

  日期：——
• Pulkkinen, Suomen Kemistilehti B, 1958, vol. 31, p. 125,127
  作者：Pulkkinen

  DOI：——

  日期：——
• Long-term therapy of chronic non-malignant pain with potent opioids in an active police officer
  作者：Peter H. K. Mak、Siu L. Tsui、K. F. Jacobus Ng

  DOI：10.1007/bf03017384

  日期：2002.6

  Purpose: To report the successful long-term use of methadone and tramadol in treating low back pain in a marine police officer.Principal findings: The patient sustained a work-related injury having fallen down stairs while on duty in 1990. After multiple operations for a prolapsed L5/S1 intervertebral disk, he was first seen at our pain clinic in 1994. Numerous systemic medications, invasive procedures, physiotherapy and psychotherapy were used to treat his pain, but without sustained effect.Methadone was started in late 1995 and tramadol in 2000. The current maintenance doses are methadone 20 mg and tramadol 200 mg, both twice daily. Apart from some initial disruption, the patient was soon able to return to full time work. Regular performance reports from his supervisors have always been excellent.Conclusion: The use of methadone in this police officer with chronic low back pain has been very successful despite the demanding nature of his job. The controversy surrounding, and further suggestions regarding long-term use of opioid therapy for nonmalignant pain are discussed.