Alloc-D-Lys(Fmoc)-OH | 1193642-32-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Alloc-D-Lys(Fmoc)-OH
• 英文别名: aloc-D-Lys(Fmoc)-OH；(2R)-6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-(prop-2-enoxycarbonylamino)hexanoic acid
• CAS: 1193642-32-8
• 化学式: C₂₅H₂₈N₂O₆
• 分子量: 452.507
• InChiKey: SVGIXLCPDFRQJL-JOCHJYFZSA-N

物化性质

• 沸点：
  689.7±55.0 °C(Predicted)
• 密度：
  1.237±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  13
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  114
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Alloc-D-Lys(Fmoc)-OH 在 哌啶 、 1-羟基苯并三唑 、 N,N'-二异丙基碳二亚胺 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 17.0h， 生成 Trt-HSG-OH
  参考文献：
  名称：

  Fluorinated carbohydrate conjugates

  摘要：

  本文披露了包括氟化碳水化合物分子的新型共轭物以及合成这些共轭物的方法。氟化碳水化合物分子可能包括放射性同位素。合成共轭物的方法可用于标记选择的分子，这些共轭物可能在诊断或治疗方法中有用。特别是，这些共轭物可能在诊断或治疗试剂盒中有用。

  公开号：

  US20050136001A1

文献信息

• Methods and Compositions for Improved F-18 Labeling of Proteins, Peptides and Other Molecules
  申请人：McBride William J.

  公开号：US20080170989A1

  公开（公告）日：2008-07-17

  The present application discloses compositions and methods of synthesis and use of F-18 labeled molecules of use, for example, in PET imaging techniques. In particular embodiments, the labeled molecules may be peptides or proteins, although other types of molecules including but not limited to aptamers, oligonucleotides and nucleic acids may be labeled and utilized for such imaging studies. In preferred embodiments, the F-18 label may be conjugated to a targeting molecule by formation of a metal complex and binding of the F-18-metal complex to a chelating moiety, such as DOTA, NOTA, DTPA, TETA or NETA. In other embodiments, the metal may first be conjugated to the chelating group and subsequently the F-18 bound to the metal. In other preferred embodiments, the F-18 labeled moiety may comprise a targetable conjugate that may be used in combination with a bispecific or multispecific antibody to target the F-18 to an antigen expressed on a cell or tissue associated with a disease, medical condition, or pathogen. Exemplary results show that F-18 labeled targetable conjugate peptides are stable in human serum at 37° C. for several hours, sufficient time to perform PET imaging analysis.

  本申请公开了合成和使用F-18标记分子的组成物和方法，例如在PET成像技术中使用。在特定实施例中，标记的分子可以是肽或蛋白质，尽管其他类型的分子，包括但不限于aptamer、寡核苷酸和核酸也可以被标记并用于这种成像研究。在优选实施例中，F-18标记可以通过形成金属配合物并将F-18金属配合物结合到螯合基团，例如DOTA、NOTA、DTPA、TETA或NETA，与靶向分子结合。在其他实施例中，金属可以首先与螯合基团结合，然后F-18与金属结合。在其他优选实施例中，F-18标记的分子可以包括可靶向的共轭物，可以与双特异性或多特异性抗体结合使用，以将F-18靶向表达在与疾病、医疗条件或病原体相关的细胞或组织上的抗原。示例结果表明，F-18标记的可靶向共轭肽在37℃的人血清中稳定数小时，足以进行PET成像分析。
• Improved ¹⁸F Labeling of Peptides with a Fluoride-Aluminum-Chelate Complex
  作者：William J. McBride、Christopher A. D’Souza、Robert M. Sharkey、Habibe Karacay、Edmund A. Rossi、Chien-Hsing Chang、David M. Goldenberg

  DOI：10.1021/bc100137x

  日期：2010.7.21

  We reported previously the feasibility to radiolabel peptides with fluorine-18 (F-18) using a rapid one-pot method that first mixes F-18(-) with Al3+ and then binds the ((AlF)-F-18)(24) complex to a NOTA ligand on the peptide. In this report, we examined several new NOTA ligands and determined how temperature, reaction time, and reagent concentration affected the radiolabeling yield. Four structural variations of the NOTA ligand had isolated radiolabeling yields ranging from 5.8% to 87% under similar reaction conditions. All of the (AlF)-F-18 NOTA complexes were stable in vitro in human serum, and those that were tested in vivo also were stable. The radiolabeling reactions were performed at 100 C, and the peptides could be labeled in as little as 5 mm. The IMP467 peptide could be labeled up to 115 GBq/mu mol (3100 Ci/mmol), with a total reaction and purification time of 30 min without chromatographic purification.
• Fluorinated carbohydrate conjugates
  申请人：McBride J. William

  公开号：US20050136001A1

  公开（公告）日：2005-06-23

  Disclosed are novel conjugates that include fluorinated carbohydrate molecules and methods for synthesizing the conjugates. The fluorinated carbohydrate molecule may include a radioisotope. The method of synthesizing the conjugate is useful for labeling selected molecules, and the conjugates may be useful in diagnostic or therapeutic methods. Particularly, the conjugates may be useful in diagnostic or therapeutic kits.

  本文披露了包括氟化碳水化合物分子的新型共轭物以及合成这些共轭物的方法。氟化碳水化合物分子可能包括放射性同位素。合成共轭物的方法可用于标记选择的分子，这些共轭物可能在诊断或治疗方法中有用。特别是，这些共轭物可能在诊断或治疗试剂盒中有用。