| 1046469-74-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1046469-74-2
• 化学式: C₂₅H₂₉BrO₃SSi
• 分子量: 517.559
• InChiKey: QKHOYOJPHWYLAM-BHDDXSALSA-N

反应信息

• 作为产物：
  描述：

  在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 1.0h， 生成 、
  参考文献：
  名称：

  Efficient Synthesis of Ratiometric Fluorescent Nucleosides Featuring 3-Hydroxychromone Nucleobases

  摘要：

  The synthesis of a novel class of fluorescent nucleosides featuring 2-aryl-3-hydroxychromones (3-HC) as base analogues is described. Nucleoside la bearing the 2-thienyl-3-HC nucleobase was prepared using sequential aryl-aldol condensation/cycloetherification or a Friedel-Crafts glycosylation as key steps. The synthesis of the triazolyl derivative 1b was achieved using a convergent 1,3-dipolar cycloaddition strategy. Fluorescence studies show that 3-HC-thienyl-nucleoside la displays high sensitivity of its dual emission to polarity changes and therefore is highly promising for nucleic acid labelling. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.07.021

文献信息

• Efficient Synthesis of α- and β-2′-Deoxy-heteroaryl-<i>C</i>-nucleosides
  作者：Alain Burger、Rachid Benhida、Marie Spadafora

  DOI：10.1055/s-2008-1072589

  日期：2008.5

  A short and efficient method for the synthesis of a series of 2′-deoxy-heteroaryl- C-nucleosides has been developed by the application of aryl-aldol condensation followed by P-toluenesulfonic acid (PTSA)-mediated isopropylidene cleavage and subsequent cycloetherification.

  通过应用芳基-羟醛缩合，然后对甲苯磺酸 (PTSA) 介导的异亚丙基裂解和随后的环醚化，开发了一种短而有效的合成一系列 2'-脱氧-杂芳基-C-核苷的方法。