[(1,4,5-(2)H3)-1H-pyrazol-3-yl](2,N,N',N'-(2)H4)acetohydrazide | 1150098-64-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [(1,4,5-(2)H3)-1H-pyrazol-3-yl](2,N,N',N'-(2)H4)acetohydrazide
• CAS: 1150098-64-8
• 化学式: C₅H₈N₄O
• 分子量: 147.089
• InChiKey: SSITUPYZZXZPCE-PNENHCSXSA-N

物化性质

• 熔点：
  130-132 °C(Solvent: Ethanol)

反应信息

• 作为产物：
  描述：

  2-羟基-5-硝基吡啶 在 肼-D4 作用下， 反应 5.0h， 以80%的产率得到[(1,4,5-(2)H3)-1H-pyrazol-3-yl](2,N,N',N'-(2)H4)acetohydrazide
  参考文献：
  名称：

  Cyclizations of monocyclic 5-nitropyridin-2(1H)-ones

  摘要：

  Reactions of 5-nitropyridin-2(1H)-one and its N-methyl derivative with hydrazine hydrate led to the formation of (1H-pyrazol-3-yl)acetohydrazide. Under analogous conditions, 1,3-dimethyl-5-nitropyridin-2(1H-one gave rise to 2-(1H-pyrazol-3-yl)propionohydrazide, while 6-methyl-5-nitropyridin-2(1H-one was converted into (5-methyl-1H-pyrazol-3-yl)acetohydrazide. Hydrazinolysis of4-methyl-5-nitropyridin-2(1H)-one resulted in the formation of 3-methyl-4-nitro-1H-pyrazole. The mechanism of recyclization of nitropyridine derivatives by the action of hydrazine hydrate was studied using 5-nitropyridin-2(1H)-one and 1-methyl-5-nitropyridin-2(1H)-one as examples.

  DOI：

  10.1134/s1070428008080174