| 1155860-98-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1155860-98-2
• 化学式: C₁₈H₃₂O
• 分子量: 264.451
• InChiKey: GOXOSOURCHKXNT-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 1,4-二氧六环 为溶剂， 反应 22.0h， 生成 4,4-dihexylcyclohexa-2,5-dien-1-one
  参考文献：
  名称：

  NMR-based molecular ruler for determining the depth of intercalants within the lipid bilayer

  摘要：

  The development of "molecular rulers" would allow one to quantitatively locate intercalants within the liposomal bilayer. To this end, we have attempted to correlate the C-13 NMR chemical shift of a polarizable "reporter" carbon (e.g., carbonyl) of the intercalant-with the E-T(30) polarity it experiences, and with its Angstrom distance from the interface. This requires families of molecules with the same two "reporter carbons" separated by a fixed distance, residing at various depths/polarities within the bilayer. The families studied included 4,4-dialkylcyclohexa-2,5-dienones 1, benzenediacetic esters 15, benzenedipropionic esters 17, 4-alkoxybenzaldehydes 19 and methyl 4-alkoxybenzoates 22. These compounds possessed the following characteristics: (1) a planar backbone; (2) polar/hydrophilic "head" groups: (3) modular hydrophobic tails; (4) large changes in the C-13 NMR chemical shift (Delta delta) of the reporter atoms with sol- vent polarity. These studies revealed a fifth requirement, namely: (5) the reporter carbons must not be strongly conjugated, lest it reflect the charge build-up at another site within the conjugated system. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

  DOI：

  10.1016/j.chemphyslip.2008.07.004