O-ethyl S-(1-(1-((6-fluoropyridin-2-yl)oxy)cyclobutyl)-2-(2-oxotetrahydrofuran-3-yl)ethyl) carbonodithioate | 1345831-22-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: O-ethyl S-(1-(1-((6-fluoropyridin-2-yl)oxy)cyclobutyl)-2-(2-oxotetrahydrofuran-3-yl)ethyl) carbonodithioate
• CAS: 1345831-22-2
• 化学式: C₁₈H₂₂FNO₄S₂
• 分子量: 399.507
• InChiKey: QROJGICOLSAKGP-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  O-ethyl S-(1-(1-((6-fluoropyridin-2-yl)oxy)cyclobutyl)-2-(2-oxotetrahydrofuran-3-yl)ethyl) carbonodithioate 在 DTBP 作用下， 以 氯苯 为溶剂， 反应 1.75h， 以68%的产率得到3-(2-cyclobutylideneethyl)dihydrofuran-2(3H)-one
  参考文献：
  名称：

  Elimination versus Ring Opening: A Convergent Route to Alkylidene-Cyclobutanes

  摘要：

  Functionalized alkylidene-cyclobutanes have been prepared from 2-fluoropyridinyl-6-oxy precursors derived from vinyl cyclobutanols by a radical addition elimination process. A wide range of functional groups is tolerated, and the alkylidene-cyclobutanes can be further elaborated Into cyclopentanones. The limitation of this approach resides in the competition with opening of the cyclobutane ring.

  DOI：

  10.1021/ol202798r